DNA-NEWBIE-L ArchivesArchiver > DNA-NEWBIE > 2008-12 > 1230543504
From: Nelda Percival <>
Subject: [DNA-NEWBIE] SNV versis SNP
Date: Mon, 29 Dec 2008 03:38:24 -0600
First I have never heard of SNVs... So I asked on the Genealogy-dna list where most of the experts are.
I recieved this responce" In a message dated 12/28/2008 11:28:49 PM Pacific Standard Time, writes: > In reference to mtdna> What is a SNV? I was told that in comparing mtdna results you were comparing > SNVs and I've never heard of them I understood that mtdna was testing SNPs. > and you compared SNP mutations .... I hadn't heard of that. Maybe Single Nucleotide Variation instead of Single Nucleotide Polymorphism???
I look at that and wonder if she isn't correct, because a SNP mutation which is what you compare could be refered to as a variation. Ann is quite knowledgeable in dna studies and has written a book or two..
You asked me what I compared.. Well I was tested at Sorensons and they tested HVR 1, HVR 2, and HVR 3. Not all companies seperate the HVRs into three groups most only seperate the regions into two, along with the coding region. I was not tested in the coding region. Thus my H haplogroup, is not seperated into subclades. I will need to test the coding region for that. (Which Soirenson's does not do for free)...
So my results below are the mutation differences I have from the Cambridge model
location 16519, your sequence C, reference T,
location 152, your sequence C, reference Tlocation 263, your sequence G, reference Alocation 309.1, your sequence C, reference --location 315.1, your sequence C, reference --
Basically our mtDNA was analyzed and then compared to a standard mitochondrial sequence established in 1981 at Cambridge. That analysis is known as the Cambridge Reference Sequence (CRS). Our analysis was then compared to this standard to find sequencing differences.
HVR1: tests from 16001 to 16520
HVR2: tests from 1 to 400
The main goal of mtDNA testing is to gain a complete understanding of all of the important SNP mutations in your mtDNA. The HVR-1 test focuses on markers in the HVR-1 region, the HVR-2 test focuses on markers in the HVR-2 region, and the SNP Test Panels focus on relevant markers in the Coding Region. (from GeneTree.com)
If you go to:
MitoSearch is a free data base sponsored by Family Tree DNA that allows individuals who have obtained their results from any testing company to enter their information and search for matches.
Also you can go to http://www.dna-fingerprint.com and input your data to see who compares.
There is also Sorenson's at http://www.smgf.org/index.jspx
|[DNA-NEWBIE] SNV versis SNP by Nelda Percival <>|