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Archiver > GENEALOGY-DNA > 2002-02 > 1013311679


From:
Subject: [DNA] Distribution of alleles
Date: Sat, 9 Feb 2002 22:28:02 EST


In a message dated 02/08/02 4:18:37 PM Pacific Standard Time,
writes:


> In looking over the Leiden site, I noticed one surprise: the distribution
> of alleles in their tables is different from what I would have expected
> based on the AMH. For example, on DYS 392, the AMH has 13, but the
> Leiden table shows the European mode (with 43%) at 11 and only a
> secondary peak (with 27%) at 13. Also, on DYS 391, the AMH has 11, but
> the Leiden table shows a close race with the actual mode at 10 (with
> 55%) edging out 11 (with only 40%). I find, too, that the YSTR database
> roughly confirms this surprising result. Has nobody commented on this
> before?
>

Interesting observation! Off-hand, I don't recall any comments about the
distribution of individual alleles. It takes some digging in the Y-STR
database to pull this information out. It will be handy to have Nancy's
tables when she gets around to it.

I expect the explanation is "linkage disequilibrium." The markers are all
linked together on one chromosome, and we are seeing the history of which
alleles have travelled together over the years.



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