GENEALOGY-DNA-L Archives
Archiver > GENEALOGY-DNA > 2002-08 > 1028501301
From:
Subject: Re: [DNA] Test Variability
Date: Sun, 4 Aug 2002 18:48:21 EDT
In a message dated 08/04/02 3:23:40 PM Pacific Daylight Time,
writes:
> When I first read that I understood it to mean a two step mutation occurs 1
> out of 14 transmission events.
No, sorry -- of 14 mutations, 1 mutation was a two-step and all the others
were one-step (Kayser). I'd have to review Heyer's paper, but I think all the
mutations there were one-step. Bianchi, the other author whose data is
combined with Kayser and Heyert to get our "standard" mutation rate of .002
per locus, observed NO mutations at all in his data set. If you search the
archives for those author names, I believe I have posted full citations at
some time in the past. Sorry, I don't have time right now to look them up.
Re your other question DYS388, the above authors didn't use that STR in their
research, so the mutation rate has been studied directly. However, the a
priori assumption is that it will be similar. The STRs on other chromosomes
often fall in the same range, so that's the best guess until proven otherwise.
Ann
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