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Archiver > GENEALOGY-DNA > 2002-11 > 1037762002


From: "Richard Hite" <>
Subject: [DNA] MRCA calculations
Date: Tue, 19 Nov 2002 22:15:06 -0500
In-Reply-To: <JCHBN.021119.135342.RC0@CUVMB.CC.COLUMBIA.EDU>


I see a consensus emerging here that on a 25-marker test (such as that
offered by Family Tree DNA) any less that 22 matches is considered
unrelated. In a study I am involved in, we have one case of a 21/25 match
between two individuals with a solid paper trail back to a common ancestor
(a total of 15 transmissions). Two of the differences, however, are on DYS
464. These are the readings:

Subject ASubject B
464a1517
464b1717
464c1718
464d1718

Just for the record, the other mismatches are at DYS 388 (A=11, B=12) and
DYS 458 (A=16, B=18). They match on all the other markers.

I understand the readings on the four locations at DYS 464 are linked
somehow, but I am not clear on how they are linked. But if I'm
understanding correctly, I should see the two differences on 464 as one
mutation rather than two.

I should point out that these two men are much more similar to each other
than they are to any other men in this surname study so far (a total of 17
results). Any comments?

Richard Hite

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