GENEALOGY-DNA-L Archives

From:
Subject: Re: [DNA] Italian markers [16148T]
Date: Sat, 1 Feb 2003 19:45:12 EST

In a message dated 01/31/03 6:59:16 PM Pacific Standard Time,
writes:

> Hi! I too have been lurking around the edges of the Forum, hoping to be able
>
> to comprehend the more able contributors. I would like to get your ideas on
>
> the origins of my Mother's DNA scores. She is Haplotype H, with Mutations
> at
> 16148T and 16519C. Does anyone know where in Europe this would place her?

You can look up her mutations in the Mitochondrial DNA Concordance

http://shelob.bioanth.cam.ac.uk/mtDNA/

This is a database of sequences reported by various researchers. Most
researchers did not sequence clear out to position 16519, so you can simply
look for 16148[T]. You can also consider records which has an [o] at the
beginning, e.g. 16024[o] or 16024-16089[o]. The "o" means those positions
were omitted from the original research article, but chances are reasonable
that you would match anyway.

Your haplotype is quite rare -- there were only two records in the
Concordance, one an Afro-Carib and one a Welsh. The Afro-Carib sample doesn't
make much sense if the maternal ancestry was completely African, since most
Africans have a greater number of differences from the Cambridge Reference
Sequence (CRS) than most Europeans.

The fact that one sample was found in Wales does not mean that YOUR ancestors
ever lived there, merely that someone alive today resides in Wales.

As Grant mentioned, the 16519C mutation appears to crop up quite often in the
reports we've had on this mailing list. It's possible that the CRS actually
has the less common base at that position.

Ann Turner
GENEALOGY-DNA List Administrator
>http://lists.rootsweb.com/index/other/Miscellaneous/GENEALOGY-DNA.html
DNA preservation kits: >http://www.dnafiler.com

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