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From: "Steven C. Perkins" <>
Subject: [DNA] Comprehensive analysis of Alu-associated diversity on the human sex chromosomes
Date: Mon, 01 Dec 2003 11:20:24 -0500


Noted on another list:

Gene. 2003 Oct 23;317:103-10. Related Articles, Links

Comprehensive analysis of Alu-associated diversity on the human sex
chromosomes.

Callinan PA, Hedges DJ, Salem AH, Xing J, Walker JA, Garber RK,
Watkins WS, Bamshad MJ, Jorde LB, Batzer MA.

Department of Biological Sciences, Biological Computation and
Visualization Center, Louisiana State University, 202 Life Sciences
Building, 70803, Baton Rouge, LA, USA

A comprehensive analysis of the human sex chromosomes was undertaken to
assess Alu-associated human genomic diversity and to identify novel Alu
insertion polymorphisms for the study of human evolution. Three hundred
forty-five recently integrated Alu elements from eight different Alu
subfamilies were identified on the X and Y chromosomes, 225 of which were
selected and analyzed by polymerase chain reaction (PCR). From a total of
225 elements analyzed, 16 were found to be polymorphic on the X
chromosome
and one on the Y chromosome. In line with previous research using other
classes of genetic markers, our results indicate reduced Alu-associated
insertion polymorphism on the human sex chromosomes, presumably
reflective
of the reduced recombination rates and lower effective population sizes
on
the sex chromosomes. The Alu insertion polymorphisms identified in this
study should prove useful for the study of human population genetics.

Regards,

Steven C. Perkins

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