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Archiver > GENEALOGY-DNA > 2004-01 > 1073187112


From: "Dra. Ana C. Oquendo Pabón, M.D." <>
Subject: [DNA] EA vs NA
Date: Sat, 03 Jan 2004 22:32:01 -0500
References: <13624-3FF78341-967@storefull-3132.bay.webtv.net>
In-Reply-To: <13624-3FF78341-967@storefull-3132.bay.webtv.net>


The Blackwell synergy site was down for maintenance until today. For
those who are were not able to find the reference, and are interested,
this is the abstract.

Bandelt, H.-J., Herrnstadt, C., Yao, Y.-G., Kong, Q.-P., Kivisild, T.,
Rengo, C., Scozzari, R., Richards, M., Villems, R., Macaulay, V.,
Howell, N., Torroni, A. & Zhang, Y.-P. (2003)

Identification of Native American Founder mtDNAs Through the Analysis of
Complete mtDNA Sequences: Some Caveats.
Annals of Human Genetics 67 (6), 512-524. November 2003

In this study, a detailed analysis of both previously published and new
data was performed to determine whether complete, or almost complete,
mtDNA sequences can resolve the long-debated issue of which Asian mtDNAs
were founder sequences for the Native American mtDNA pool.
Unfortunately, we now know that coding region data and their analysis
are not without problems. To obtain and report reasonably correct
sequences does not seem to be a trivial task, and to discriminate
between Asian and Native American mtDNA ancestries may be more complex
than previously believed. It is essential to take into account the
effects of mutational hot spots in both the control and coding regions,
so that the number of apparent Native American mtDNA founder sequences
is not erroneously inflated. As we report here, a careful analysis of
all available data indicates that there is very little evidence that
more than five founder mtDNA sequences entered Beringia before the Last
Glacial Maximum and left their traces in the current Native American
mtDNA pool.

* I'll be waiting to download this one when it is available online.

Regards,
Ana

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