GENEALOGY-DNA-L Archives
Archiver > GENEALOGY-DNA > 2004-03 > 1080536701
From: "hamman" <>
Subject: RE: [DNA] Some thoughts about the near future--how many STRs??
Date: Sun, 28 Mar 2004 23:05:14 -0600
In-Reply-To: <20040328043947.8114.qmail@web20002.mail.yahoo.com>
Excellent question, Peter, when will we have tested enough YSTR markers so
that we can extrapolate those results to our entire Y-chromosome? In other
words, when will we have tested enough markers so that we can no longer gain
any benefit in testing more STR markers?
Does anyone out there know how many STR loci exist in an average
Y-chromosome? Of course, we'll have to define an STR loci, for example a
site on the Y-chromosome where about 3 nucleotides are repeated at least 6
times.
Are the majority of people upgrading from 25 to 37 really gaining much
benefit, or have most already got about all they need to know at 25?
What percentage of people taking SNP tests have been coming back right away
in the haplogroup that was predicted based on their 12-marker YSTR test?
Brian Hamman
-----Original Message-----
From: Peter J. Roberts [mailto:]
Sent: Saturday, March 27, 2004 10:40 PM
To:
Subject: RE: [DNA] Some thoughts about the near future
Thank you Dean.
Hopefully others (and some experts) will still share
their thoughts.
Do we need our entire personal Y-chromosome sequenced?
I would think we just need SNP tests of those areas
which will identify our sub clad. Knowing our sub
clad and a "sufficient" number of STR markers should
allow us to only have close matches with close
relatives. I wonder how many markers is sufficient?
Sincerely, Peter
From: "Dean McGee" <>
Subject: RE: [DNA] Some thoughts about the near future
Date: Sat, 27 Mar 2004 23:03:48 -0500
In-Reply-To: <<>>
> From:
[mailto:]
> Sent: Saturday, March 27, 2004 10:02 PM
> Since I posted the link to this article to the list
when it
> first came out,
Thanks for posting it. I really enjoyed that article.
> I was quite aware of it. There is nothing in it that
would
> support Peter's
> contention that DNA could be used to reconstruct
pedigrees. I
> suspect that
> George Church, like many (most?) academics,
considers
> genealogical testing to be a
> frivolous use of DNA.
Yes, genealogists will probably always have to be
content with the
crumbs left from other market driven development. I
didn't take Peter's
message to suggest reconstructing entire pedigrees but
rather male line
descendancies. If the entire personal Y-chromosome
can be sequenced
then it may indeed be possible to identify individual
paternal ancestors
by SNPs given enough tested descendants.
-Dean
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