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From:
Subject: Re: [DNA] New mtDNA results in H 16519C [309.2]
Date: Mon, 29 Mar 2004 19:55:16 EST
In a message dated 03/29/04 12:35:44 PM Pacific Standard Time,
writes:
> My HVR1 and HVR2 results from FTDNA report the following mutations: (HVR1)
> 16519C, and (HVR2)
> 263G, 309.1C, 309.2C, and 315.1C.
>
> I cut and pasted the CRS table into Excel (moving the data into rows of ten
> fields containing
> 10 markers each), and edited the table to show my mutated values in red,
> but, I'm not sure if
> I represented 309.1C and 309.2C correctly. I added a ".1" and ".2" in
> superscript after the
> C at 309. Is this how the data should be represented in a spreadsheet?
There's no standard way to do it, so you can pick whatever style suits you --
but most people simply list their mutations instead of the whole CRS.
> That is, do the 309.1C and 309.2C mutations mean that there are three Cs at
> 309, where there
> is one C in the CRS? If so, how many such mutations can take place at any
> given marker? It
> doesn't mean that there are 12 markers in the sequence, does it?
The mtDNA molecule from the CRS (Cambridge Reference Sequence) has 16569
bases. It's a circular molecule, so the numbering begins at an arbitrary starting
point. Starting at position 303, there are a bunch of C's in a row, which
sometimes causes the DNA replicating enzyme to lose track of where it is (I'm
anthropomorphising here!). The CRS has 7 C's in a row, so the C's end at position
309. It turns out that the CRS actually has fewer C's than most people, but
it's the standard, so other people will be labeled 309.1, 309.2, etc. if they
have more C's. A reading of 309.1 is common, 309.2 is less so. A similar thing
happens when you have 315.1.
> I assumed that my mtDNA test results must be common, since I've got a
> gizillion HVR1 matches,
> and 16 HVR2 matches in FTDNA's database. Is the 309.2C less common than the
> others? Like
> only half of the world's population, instead of three-quarters?
>
The 309.2 is undoubtedly cutting down your matches in HVR2. That's good!
Ann Turner - GENEALOGY-DNA List Administrator
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