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Archiver > GENEALOGY-DNA > 2004-05 > 1083612937


From: "Whit Athey" <>
Subject: RE: [DNA] odd mtdna
Date: Mon, 3 May 2004 15:35:37 -0400
In-Reply-To: <40966D4C.3020808@inksite.com>


Hi Whitney,

These HVR1/HVR2 results are rather unusual. I am going to hazard a guess as
to where this haplotype fits into the haplogroup scheme, but I should start
by saying there are some problems with it. I only ask that you remember
that there are going to be problems with any other prediction that one could
come up with.

Torroni et al [Postglacial Recolonization of Europe, Am J Hum Gen, 2001]
studied Haplogroup V haplotypes occurring in a population of over 10K
individuals. They found 214 who were actually in V on the basis of their
status at the defining sites 4580, 14766, and 15904. They also had
sequenced HVR1 and HVR2. They found considerable variation at the HRV2
sites 072-073, which are often used to distinguish haplogroups V and H. In
this group of 214 haplotypes, two were 073G, as in your father's haplotype.
They also found 17 cases of 072T, which presumably you also have (since it
is in CRS). I admit that there were no examplea found in this V sample of
both 72T and 73G in the same haplotype. Your other three HVR2 mutations are
identical to mine, and I'm also in V.

Nearly all haplogroup V folks have 16298C, but your haplotype doesn't.
Torroni also reported four V haplotypes that had 16256T, but not 16298C.
Torroni actually used 16256T as part of his screen to identify candidate V
haplotypes, and all who had 16256T were found to be in Hg V on the basis of
the diagnostic RFLP markers.

Therefore, it appears to me that your father's haplotype is most likely in
Haplogroup V. If so, it is admittedly not your typical V. RFLP tests to
check the status at 4580 and 15904 would tell you for sure.

Whit


-----Original Message-----
From: Whitney Keen [mailto:]
Sent: Monday, May 03, 2004 12:03 PM
To:
Subject: [DNA] odd mtdna

Hello everyone:

My father (the space alien) has very odd mtdna. First of all he does not
have the mutation at 519. Now that I have gotten his HVR1 and HVR2
Mutations, Bennett Greenspan tells me that they still cannot place him
in a haplogroup. So to debbie with only one mutation, welcome to the
land of the weird.

His mutations as follows:

HVR1 16172C
16223T
16256T
16339G

HVR2 73G
263G
309.1C
315.1C

No matches, and no near matches. Any further input? FTDNA also checked
for error and says, no error. My father's mother's family were English
New Englanders as far as we know. His Y tests out to I, which is
consistent with family history and tradition. I am at a loss as to what
to tell him, except that maybe Doniken was right and some space aliens
landed in Mesopotamia back in the Bronze Age, and perhaps he is
descended from these people. :-D ( I do not really believe this, but it
makes a good story). Now that I feel relatively confident that the
results are accurately presented, I guess I should add them to Charles
Kerschner's roster. I was holding off pending the possibility that
there was either a transcription error or a lab error. Apparenly not.

Whitney Keen


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