GENEALOGY-DNA-L ArchivesArchiver > GENEALOGY-DNA > 2005-03 > 1111438956
From: "Ian & Mary Logan" <>
Subject: Re: [DNA] Question MtDNA haplogroup - Longevity
Date: Mon, 21 Mar 2005 21:02:36 -0000
I think you will find this paper of interest as it tries to explain why mutations about '150'
might affect longevity.
A Combination of three common inherited mitochondrial DNA polymorphisms
promotes longevity in Finnish and Japanese subjects.
Niemi, et al. University of Oulu, Finland
European Journal of Human Genetics 13, 166-170 (2005).
OK. perhaps it is a bit of research that was published because the worker had done it, .... .
But what I really find poor is 'the matching of the subjects' or rather 'non-matching' - I think
all that was done was to look at the subjects ages and no account of the 'disease' or 'health' profile.
was taken at all.
So is there a link between longevity & Haplogroup J - personally I doubt it.
Both my mother in law (lived to be 104) and my greatgrandfather's sister (lived to be 100) were mtDNA haplogroup J. I
believe that there are some studies linking J to longevity. I did not know about HVR2. I guess it all boils down to
the efficiency of oxidative phosphoylation (Krebs Cycle) and how well the cells are then able to carry our their
metabolic functions. I would like to see some evidence as to the result of this supposed efficiency. Perhaps it allows
for the better emulsification (breaking up) of lipofuscin (age pigments in the cell).
-------------- Original message --------------
> But just one last word ...... Cindy is '150T' and this has been said to be
> associated with
> 'longevity' - so Cindy is lucky to have this, and also lucky having a rarity
> Any centenarians in your family, Cindy ?
> Comments anyone.
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