GENEALOGY-DNA-L ArchivesArchiver > GENEALOGY-DNA > 2005-05 > 1115591647
Subject: Re: [DNA] mtDNA A to Z - Importance of 16223
Date: Sun, 08 May 2005 22:34:07 +0000
Thanks for this info Ann.
Haplogroup F is particularly problematic, and of course the most interesting for my purposes. 16304 would appear to be necessary but not sufficient. In effect it is the "defining" number for haplogroup F, but it is unclear from the chart below if 16233 is also required (it is present in most of the few F sequences that have been fully typed). It also appears the 16304 is common for haplogroup H. There are a few sequences such as 16304C 16311C 16391A which suggest F3, but I suspect are really H (had we the coding region information). I have never had the "pleasure" of working with a large mtDNA database with so many sequences whose haplogroup can only be guessed at. When we collect similar data it will be assessed with the interests of genetic genealogists in mind.
-------------- Original message --------------
> In a message dated 05/08/05 12:56:00 PM Pacific Daylight Time,
> > What struck me in the investigation of haplogroup assignment from haplotype
> > is how difficult it is unless you can find an exact sequence in the mtDNA
> > Concordance for example. One of the huge problems in my quest to find a few
> > Central Asian motifs in the lot is that 16233 is a defining ancestral sequence
> > type for haplogroups A, B, C, D, E, F, G, I, L, M, N, W, and X. How can one
> > possibly assign a haplogroup from a haplotype unless by chance there is a
> > published sequence that exactly matches on in the database one is exploring?
> This is tangential to your basic lament -- the difficulty of defining a motif
> for many haplogroups -- but a mutation at 16223 demarcates superhaplogroup R,
> the mother of many European haplogroups including H. Since we are really
> looking at *differences* from the Cambridge Reference Sequence, 16223 appears in
> all the other haplogroups before the branch point to Haplogroup R. This diagram
> illustrates that. Also note that 16223 is underlined, which means that
> parallel mutations have been observed in other haplogroups.
> Ann Turner - GENEALOGY-DNA List Administrator
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