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From:
Subject: Re: [DNA] DNA replication vs Haplotype: mutation rate variation
Date: Wed, 11 May 2005 22:48:27 EDT



In a message dated 5/11/2005 8:45:44 A.M. Pacific Standard Time,
writes:

You also have to show whether the probable difference
in up/down rates for different allele values for the same
marker is really true. If it is, this would of course
cause differences in overall rate for different haplogroups
if their modal values differed.



What the data has shown, if I recall, is that the longer the allele, there
appears to be a faster mutation rate and a tendency to mutate down on the next
mutation.....

So perhaps we should take a careful look at which markers in each haplogroup
have modals near the upper end of the range for the marker? Or maybe look
at haplotypes which have multiple markers near the upper end of the range?
Couldn't having several in this situation cause a SHORT-TERM faster mutation?
And end up with groups with what appear to be "too many" mutations for the
timeframe? I don't know. Just an idea.

In going over the data logged at Charles Kerchner's mutation rate, the 5
observations with more than 1008 (TE*markers) have greater than expected number
of mutations, one 4 more than the expected value. Yeah yeah a small number --
BUT below that there is a mix -- just above, just below, the occasional "very
different" up or down. Then it's ALL "more than expected." The smallest
difference from expected is 0.9 higher and the largest is over 4 higher than
expected. Maybe it's worth looking at these five (and the other few with
smaller total opportunities which show 1+ higher mutations) to see if there are
markers near the endge of the range for the marker?

Anne


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