Archiver > GENEALOGY-DNA > 2005-05 > 1117027055

Subject: Re: [DNA] yDNA, dys464, infertility in males
Date: Wed, 25 May 2005 09:17:35 EDT

In a message dated 5/24/05 12:59:31 PM Pacific Daylight Time,

> I am not sure why Jobling is "picking on" 464 when there are many other
> markers whose deletion could signal infertility. In the orignal paper that
> flagged the "problem", King et al. note that other markers are "so well
> established , however, that it is unlikely they will be abandoned". Just as an
> example DYS388 and the binary SNP marker M173 (R1) are found in the AZFa region;
> while P25 which identifies R1b is in the AZFc region. AZFc deletions, where
> DYS464 is located, are estimated at 1 in 100,000 men; and AZFa the rate is 1 in
> 4000 - so I am not sure where Jobling gets this new figure which seems to
> contradict his own data. It sould be noted that AZFc deleted males have been
> known to father children so the matter is much more complex than this
> newspaper article would lead one to believe.

Where are you getting the data on the frequency of the AZFa and AZFc
deletions? The King/Jobling article has the reverse of what you wrote.

Ann Turner

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