Archiver > GENEALOGY-DNA > 2005-06 > 1118263940

From: Robert Stafford <>
Subject: Re: [DNA] DNA Analysis for Conventional Genealogy vs. Deep Ancestry
Date: Wed, 8 Jun 2005 13:52:20 -0700 (PDT)
In-Reply-To: 6667

Several of us are looking for branch tags by upgrading as much as possible. In our project, we found several mutations that define branches.

However, parallel mutations can be a big problem with higher mutation rates and/or a lot of people. This calls for some extra care in testing documented lines. Once you see around ten mutations you have about a 50/50 chance of one parallel mutation using 40 markers.

We found a good early mutation at DYS438, a slower marker. However, we ran into three mutations that appear to be in parallel on DYS439, a faster marker. They occurred where the paper trail is excellent, so we weren't misled. However, beyond the paper trail, they could have been a real problem.

Bob Stafford

"Kenneth V. Graves" <> wrote:
In a previous message I wrote:
Are there techniques that we could be developing that would better allow
determining exact connections? I suspect that if we tested enough markers
(perhaps including types that are not now tested) we would find that for
each transmission event there is some sort of change/mutation. Although some
of these might not have long-term stability, we might be able to find
something unique for each transmission event, allowing us to pinpoint the
exact connection with a lineage. Maybe some enterprising person could even
find a way to screen the genome for changes connected with a specific
transmission event or lineage.

I was mainly referring to Y-DNA testing in this paragraph. I also realize
that any methodology for doing this might require many descendants of a
common ancestor to be tested, and that we have previously discussed on this
list the value of testing more markers. My question is: Do any of our
experts see the general concept of the preceding paragraph as promising?


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