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Archiver > GENEALOGY-DNA > 2005-06 > 1118451842


From: "Dale E. Reddick" <>
Subject: Re: [DNA] High Mutation Rate in Second Cousins
Date: Fri, 10 Jun 2005 21:06:02 -0400
References: <061120050029.11944.42AA3065000B3E5600002EA82200734840050B989A0E00@comcast.net>
In-Reply-To: <061120050029.11944.42AA3065000B3E5600002EA82200734840050B989A0E00@comcast.net>


Hey David,

Recall the ol' bell-shaped curve. Consider sampling. Remember that
someone has to represent the outriders of reality - as we find such to
exist. You and the rest of your Faux relatives represent the 99.99th
percentile of the presently known collection of those who've undergone
DNA testing in terms of internal divergence. Y'all are the statistical
fluke.

And above all - chance rules - even in genetics!

So, you and your relatives have established a new level of diversity of
mutation within a single, documented lineage! Nothing more, nothing less.

Dale
________________________________

David Faux wrote:

>List:
>
>I received the last panel of 13 markers from FTDNA today and the results were quite dramatic.
>
>Previously my Dad's second cousin, "RF" (MRCA born 1814) and he matched only 23/25. All 13 markers of the second panel match and there are no matches at even 22/25 except with other Fauxes. The R1b signature is very rare at that level of resolution.
>
>Now the match drops to 32/37. What is very strange is that a distant cousin, "IF" (MRCA bon 1618) also mismatches both of us on 3 of the four markers. What is it about those four markers and the Faux family?
>
>Here are the results:
>
>DYS390 = 25 DF; 24 RF; 24 IF
>DYS439 = 12 DF; 13 RF; 14 IF
>DYS576 = 17 DF; 18 RF; 16 IF
>DYS570 = 17 DF; 19 RF; 18 IF
>
>The paper trail is without question and as I said the signature is rare enough that there are no others except Fauxes in 18,000 that match even 22/25.
>
>Anyone have any ideas why these four markers, especially the last three where all parties differ, should be consistent mutators - chance factors? I may have the dubious record of having the largest number of mutations per transmission yet known in a fully documented family. I guess I need to have my Dad tested for the last 13 markers in case he and I differ.
>
>Any notions of what is going on?
>
>David F.
>
>
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>

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