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Archiver > GENEALOGY-DNA > 2005-06 > 1118452663


From: "" <>
Subject: RE: [DNA] High Mutation Rate in Second Cousins
Date: Fri, 10 Jun 2005 21:17:43 -0400


570 and 576 can move around quite a bit. I think you have run into a
situation in which fast mutators have done what it is they do. They just
happened to do it within the last few generations of a family that you
follow closely.

David W.

Original Message:
-----------------
From: (David Faux)
Date: Sat, 11 Jun 2005 00:29:25 +0000
To:
Subject: [DNA] High Mutation Rate in Second Cousins


List:

I received the last panel of 13 markers from FTDNA today and the results
were quite dramatic.

Previously my Dad's second cousin, "RF" (MRCA born 1814) and he matched
only 23/25. All 13 markers of the second panel match and there are no
matches at even 22/25 except with other Fauxes. The R1b signature is very
rare at that level of resolution.

Now the match drops to 32/37. What is very strange is that a distant
cousin, "IF" (MRCA bon 1618) also mismatches both of us on 3 of the four
markers. What is it about those four markers and the Faux family?

Here are the results:

DYS390 = 25 DF; 24 RF; 24 IF
DYS439 = 12 DF; 13 RF; 14 IF
DYS576 = 17 DF; 18 RF; 16 IF
DYS570 = 17 DF; 19 RF; 18 IF

The paper trail is without question and as I said the signature is rare
enough that there are no others except Fauxes in 18,000 that match even
22/25.

Anyone have any ideas why these four markers, especially the last three
where all parties differ, should be consistent mutators - chance factors?
I may have the dubious record of having the largest number of mutations per
transmission yet known in a fully documented family. I guess I need to
have my Dad tested for the last 13 markers in case he and I differ.

Any notions of what is going on?

David F.


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