Archiver > GENEALOGY-DNA > 2005-06 > 1118452663

From: "" <>
Subject: RE: [DNA] High Mutation Rate in Second Cousins
Date: Fri, 10 Jun 2005 21:17:43 -0400

570 and 576 can move around quite a bit. I think you have run into a
situation in which fast mutators have done what it is they do. They just
happened to do it within the last few generations of a family that you
follow closely.

David W.

Original Message:
From: (David Faux)
Date: Sat, 11 Jun 2005 00:29:25 +0000
Subject: [DNA] High Mutation Rate in Second Cousins


I received the last panel of 13 markers from FTDNA today and the results
were quite dramatic.

Previously my Dad's second cousin, "RF" (MRCA born 1814) and he matched
only 23/25. All 13 markers of the second panel match and there are no
matches at even 22/25 except with other Fauxes. The R1b signature is very
rare at that level of resolution.

Now the match drops to 32/37. What is very strange is that a distant
cousin, "IF" (MRCA bon 1618) also mismatches both of us on 3 of the four
markers. What is it about those four markers and the Faux family?

Here are the results:

DYS390 = 25 DF; 24 RF; 24 IF
DYS439 = 12 DF; 13 RF; 14 IF
DYS576 = 17 DF; 18 RF; 16 IF
DYS570 = 17 DF; 19 RF; 18 IF

The paper trail is without question and as I said the signature is rare
enough that there are no others except Fauxes in 18,000 that match even

Anyone have any ideas why these four markers, especially the last three
where all parties differ, should be consistent mutators - chance factors?
I may have the dubious record of having the largest number of mutations per
transmission yet known in a fully documented family. I guess I need to
have my Dad tested for the last 13 markers in case he and I differ.

Any notions of what is going on?

David F.

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