Archiver > GENEALOGY-DNA > 2005-06 > 1120141779

From: Doug McDonald <>
Subject: Re: [DNA] mtDNA J*-- Why the big spread in mutations?
Date: Thu, 30 Jun 2005 09:29:39 -0500
References: <BAY103-F229A08B4C96694C3A90398CEE30@phx.gbl>
In-Reply-To: <BAY103-F229A08B4C96694C3A90398CEE30@phx.gbl>

Russ _ wrote:

> My HVR1 mutations are 16069T, 16126C, 16145A, 16325C
> My HVR2 mutations are
> 073G,150T,185A,228A,263G,295T,315.1C,462T,482C,489C,523-,524-
> One thing I've noticed is that my HVR2 mutations are a mile long
> compared to most people's mtDNA that I'ved looked at. I was once in J1
> then they put me in J* which according to FTDNA is the root of J.
> According to their webpage J originated in the Near East 50,000 years
> ago and J* is spread all over Europe at low frequencies.

Your HVR2 is fairly typical for a J.

73 and 263 get you out of H, where the CRS is.

295 and 489 gets you into J. At this point different papers differ
in notation. I recommend a careful study of Herrnstadt,
Am. J. Hum. Genet. 70:1152–1171, 2002 and
Palanichami, Am. J. Hum. Genet. 75: ? (I don't have page since
I copied it from the "online first"). Only Palanichami has
the HVR regions, but you can compare the non-HVR regions with
Herrnstadt. 16145 is a recurrent mutation, and in your case it
is important to note that you don't have 16222, which is a more
unique designator of a branch of J where you are not, but one that
usually has 16145 also.

If I (PUAP2 at mitosearch) were you ... which I'm not, but I'm somewhat
close, lacking the 482 ... I would not worry about notation all that
much. We are both in Palanichami's J1c area. We would be in Gonzalez's
not clear what Herrnstadt would call us ... it would be either J* or J1.

But we know where we are, fairly closely, because of the excellent
papers of Palanichami and Herrnstadt.

You could also, if you like WORK, go to GenBank (Blast) and try to find
somebody who matches you fairly closely.

Doug McDonald

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