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Archiver > GENEALOGY-DNA > 2005-07 > 1120245896


From: "M True" <>
Subject: Re: [DNA] Back Mutation and Parallel Mutation
Date: Fri, 1 Jul 2005 20:24:56 +0100
References: <6.2.1.2.2.20050701112946.037e1910@lafn.org> <20050701184723.31981.qmail@web81806.mail.mud.yahoo.com> <6.2.1.2.2.20050701115851.03e3c4c0@lafn.org>


Hi,

My understanding of backmutations is that they are supposed to be
approximately half as frequent as forward mutations. Therefore the modal
marker value for the group in question should in general be the original or
ancestral value for the group as a whole. While this is often unclear in
small groups it should become more apparent as the group becomes larger.

NB I'm not sure where I heard the idea of backmutations being half as
frequent as forward ones. Is this a just theory being circulated or is
there any evidence to back it up in one of the scientific studies?

John Eckersley.


----- Original Message -----
From: "Robert Davenport" <>
To: <>
Sent: Friday, July 01, 2005 8:00 PM
Subject: Re: [DNA] Back Mutation and Parallel Mutation


>
>
> Thanks for those threads.
>
> Even more than parallel mutations, I'm kind of worried about this concept
> of back mutations.
>
> If a marker can go from 19 to 20, and then mutate back to 19 in subsequent
> generations, it's hell to pay in trying to figure out which was the
> original marker, 19 or 20.
>
>
>
>
>
>
>
>
>
>
>
> At 11:47 AM 7/1/2005, you wrote:
> >Robert,
> >
> >I searched the web last April, but couldn't find anything on parallel
> >mutations.. Considering their high likelihood when you have a lot of
> >people with the same ancestral haplotype in a project, I was surprised.
> >The only "publications" are on this list. Here are some threads where we
> >discussed parallel mutations:
> >
> >http://archiver.rootsweb.com/th/read/GENEALOGY-DNA/2005-04/1113072115
> >
> >http://archiver.rootsweb.com/th/read/GENEALOGY-DNA/2005-06/1119231461
> >
> >http://archiver.rootsweb.com/th/read/GENEALOGY-DNA/2005-06/1119874642
> >
> >Bob Stafford
> >
> >
> >
> >
> >
> >Robert Davenport <> wrote:
> >
> >
> >I'd like to hear more back from the list on parallel and back mutation.
> >
> >Is there a professional paper on this?
> >
> >
> >
> >
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>
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