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From:
Subject: Re: [DNA] Back Mutation and Parallel Mutation
Date: Fri, 1 Jul 2005 16:13:48 EDT




John ...

There's evidence to support the notion that back-mutation rates are higher
when the measured allele length is near the lower or upper limit of the
generally observed interval of lengths. E.G. a paper by Dupuy on Norwegian
father/son pairs (several refs in List archives over the past 6 months). I haven't
seen any detailed estimates of rates.

Mike ...
==================================================

In a message dated 7/1/2005 12:28:44 PM Pacific Standard Time,
writes:

Hi,

My understanding of backmutations is that they are supposed to be
approximately half as frequent as forward mutations. Therefore the modal
marker value for the group in question should in general be the original or
ancestral value for the group as a whole. While this is often unclear in
small groups it should become more apparent as the group becomes larger.

NB I'm not sure where I heard the idea of backmutations being half as
frequent as forward ones. Is this a just theory being circulated or is
there any evidence to back it up in one of the scientific studies?




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