GENEALOGY-DNA-L Archives

Archiver > GENEALOGY-DNA > 2005-07 > 1122040453


From: Robert Stafford <>
Subject: Re: [DNA] Costs, Multiplexing and Related Issues
Date: Fri, 22 Jul 2005 06:54:13 -0700 (PDT)
In-Reply-To: <072220050509.19286.42E07F79000BC8B800004B562200762194050B989A0E00@comcast.net>


Do you have citations for this statement, particularly any that apply to Marligen kits and/or Luminex 100 platforms? You seem to be implying that there is some sort of consensus out there. However, Butler and Vallone have backed the use of multiplexes. Although they can't endorse a particular product, they do use both the Marligen and SNaPShot methods. See:

http://www.cstl.nist.gov/biotech/strbase/pub_pres/Vallone2004a.pdf


Since Vallone and Butler are chemists with exellent credentials, they are much better qualified to comment on the reliability of a test than population geneticists. Do you have some indication that they have changed their view on multiplexes in general?

Bob Stafford


David Faux <> wrote:

The pop gen and forensic literature does not support the use of multiplexing at this point in time. I will be very interested to learn if things have somehow changed since early 2005 - if so it would be quite the come back for a technique that appeared to require major modifications.


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