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Archiver > GENEALOGY-DNA > 2005-09 > 1127414942


From: "David F Reynolds" <>
Subject: Re: Felstead TMRCA, hg E3b (was Re: [DNA] SMGF adjustments to FTDNA values) Mutation rate for DYS 449
Date: Thu, 22 Sep 2005 11:49:02 -0700
References: <380-220059220214337977@M2W087.mail2web.com> <43308839.6020402@dna-fingerprint.com> <REME20050920182157@alum.mit.edu> <op.sxfa9wsxpqnhvj@pablo> <009001c5be39$39effe50$0100a8c0@chrissam> <op.sxfdbclzpqnhvj@pablo> <00c101c5be3e$424f7300$0100a8c0@chrissam> <001c01c5beb5$a6d62fe0$0100a8c0@chrissam> <op.sxg1kudbpqnhvj@pablo> <003e01c5bf02$b79062e0$0100a8c0@chrissam> <op.sxg849xapqnhvj@pablo> <001801c5bfa2$3d101b00$0100a8c0@chrissam>
In-Reply-To: <001801c5bfa2$3d101b00$0100a8c0@chrissam>


First, a housekeeping note -- I haven't been snipping my responses, and I apologize to the list for that. Trimming down extraneous/old material in responses is good list netiquette, and reduces the burden on those who are subscribed in DIGEST format.
--
Mutation rates are a hotly debated topic, and there are a number of knowledgable folks on the list who can add to this.

There is a table of mutation rates at:
http://smgf.org/ASHG2004-3.pdf
that lists a mutation rate of 0.012373 for DYS449; I think this is the best data I've ran across for it (i.e., based on the number of datapoints they are basing the mutation value on). Although FTDNA notes DYS449 as "fast moving", this is a *very* fast moving value.

The .0070 value is certainly reasonable (and still "fast moving" compared to other markers), though.

Regards,
david

On Thu, 22 Sep 2005 11:19:57 -0700, Edward Felstead <> wrote:

> David
> Sorry to bother you yet again but I have contact with the individual with whom I have a
> 35/36 match.
> The mismatch is just on the one DYS ie DYS 449.
> I have been using a program I found to calculate the Time to Most Recent Common Ancestor
> and to use it I have to enter a MUTATION RATE for DYS 449.
> I have searched the internet and find the value for DYS 449(On average) to be 00.70.
> This seems particularly high when compared with other positions.
> In your experience is 00.70 a realistic value for the mutation rate of DYS 449.
> Thank you
> Best Wishes
> Edward

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