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Archiver > GENEALOGY-DNA > 2005-09 > 1127416260


From: "Ken Nordtvedt" <>
Subject: Re: Felstead TMRCA, hg E3b (was Re: [DNA] SMGF adjustments to FTDNA values) Mutation rate for DYS 449
Date: Thu, 22 Sep 2005 13:11:00 -0600
References: <380-220059220214337977@M2W087.mail2web.com> <43308839.6020402@dna-fingerprint.com> <REME20050920182157@alum.mit.edu> <op.sxfa9wsxpqnhvj@pablo> <009001c5be39$39effe50$0100a8c0@chrissam> <op.sxfdbclzpqnhvj@pablo> <00c101c5be3e$424f7300$0100a8c0@chrissam> <001c01c5beb5$a6d62fe0$0100a8c0@chrissam> <op.sxg1kudbpqnhvj@pablo> <003e01c5bf02$b79062e0$0100a8c0@chrissam> <op.sxg849xapqnhvj@pablo> <001801c5bfa2$3d101b00$0100a8c0@chrissam> <op.sxio70hnpqnhvj@pablo>


But the rate to be used in a TMRCA is the AVERAGE rate for all the markers
present in the haplotypes being compared. The individual rate for the
marker or markers seen to have mutated are not to be singled out. The only
thing that the individual rates is relevant to is how relatively often,
after lookking at many cases, you should see the different markers being the
ones that have mutated. In other words, you should see more cases of the
fast markers having mutated than the slow ones.

Ken
----- Original Message -----
From: "David F Reynolds" <>
To: <>
Sent: Thursday, September 22, 2005 12:49 PM
Subject: Re: Felstead TMRCA, hg E3b (was Re: [DNA] SMGF adjustments to FTDNA
values) Mutation rate for DYS 449
> --
> Mutation rates are a hotly debated topic, and there are a number of
> knowledgable folks on the list who can add to this.
>
> There is a table of mutation rates at:
> http://smgf.org/ASHG2004-3.pdf
> that lists a mutation rate of 0.012373 for DYS449; I think this is the
> best data I've ran across for it (i.e., based on the number of datapoints
> they are basing the mutation value on). Although FTDNA notes DYS449 as
> "fast moving", this is a *very* fast moving value.
>
> The .0070 value is certainly reasonable (and still "fast moving" compared
> to other markers), though.
>
> Regards,
> david
>


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