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Archiver > GENEALOGY-DNA > 2005-09 > 1128027592


From: (John Chandler)
Subject: Re: [DNA] STR mutation rates
Date: Thu, 29 Sep 2005 16:59:52 -0400 (EDT)
References: <1de.4490c855.306d7537@aol.com>
In-Reply-To: <1de.4490c855.306d7537@aol.com> (DNACousins@aol.com)


Ann wrote:
> As for the overall rate in the log, I haven't uploaded my data, mainly
> because I have a rather small number of transmission events in my known pedigrees.
> However, there are no mutations, and if others are behaving like me, that would
> bias the log toward a higher rate.

The obvious reply is: well, then, go ahead and upload your data. The
log at present has a total of only 14,000 mutation opportunities
(transmissions times markers) represented in the 12-marker panel.
That makes it less than a quarter of the size of the YHRD "meta-study"
comprising the various reported father-son results.

Here's a bit of statistics. 1% of the log's 12-marker "power" is made
of families with 6 or fewer transmissions; 11% is from families with
12 or fewer transmissions; 20% is from families with 24 or fewer. As
far as I can tell, the average mutation rate for the smaller family
studies is not significantly different from the overall average.

John Chandler

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