GENEALOGY-DNA-L ArchivesArchiver > GENEALOGY-DNA > 2005-10 > 1128705739
From: "Eldon Wade" <>
Subject: RE: [DNA] S21+ extends from 37 markers to 48 markers.
Date: Fri, 7 Oct 2005 13:22:19 -0400
Thanks for enlightening me.
> -----Original Message-----
> From: Doug McDonald [mailto:]
> Sent: Friday, October 07, 2005 11:22 AM
> Subject: Re: [DNA] S21+ extends from 37 markers to 48 markers.
> Eldon Wade wrote:
> >Could someone please direct me to where I can learn about
> "point variation"
> >in STRs?
> It's simple. The phrase was
> "a point variation within the region where the DYS448 primers
> usually lock on"
> Which translates into ordinary genealogy-dna-l-ese as "SNP"
> or "private SNP", or possibly a deletion or insertion or some
> sort of strange recombination event, all of which are
> equivalent to SNPs. If you get results for 448 from some
> companies but not others, this is almost surely the reason.
> To find out exactly what happened you would have to have the
> whole region sequenced.
> If the company that successfully measured 448 uses primers
> that are "outside"
> the primers used by the company that failed, it is a modestly
> feasible undertaking, though not commercially done. This
> diagram illustrates what I mean:
> DNA Strand:
> Primers Outside A Inside A
> Inside B Outside B
> Doug McDonald
> View and search Historical Newspapers. Read about your
> ancestors, find marriage announcements and more. Learn more:
|RE: [DNA] S21+ extends from 37 markers to 48 markers. by "Eldon Wade" <>|