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Archiver > GENEALOGY-DNA > 2005-10 > 1129907404


From: Thomas Krahn <>
Subject: Re: [DNA] DYS724 / DYS725 / DYS726
Date: Fri, 21 Oct 2005 17:10:04 +0200
References: <E1ESwgX-0007RR-00@pop-satin.atl.sa.earthlink.net>
In-Reply-To: <E1ESwgX-0007RR-00@pop-satin.atl.sa.earthlink.net>


David,

DYS724 was discovered by Allan Redd and seems to be an interesting
duplicated marker to study recLOH.
I have not a single population dataset on it and I have just started
developing a protocol for this marker.
Maybe FTDNA can tell you more about it or you may contact Allan Redd
directly.

I have discovered DYS725 when searching for differences in the 4 DYS464
regions. It is also a quadruplicated marker like DYS464 and it is in
close proximity to the former one. The problem with DYS725 is, that it
is a dinucleotide repeat and very difficult to read. You know the
difficulties from reading extended DYS464 alleles. At DYS725 there is
additionally a very strong stutter band for each of the four alleles.
DYS725 seems to have interestingly short alleles in the I haplogroups.
I still haven't cycle sequenced the exact number of alleles. This marker
isn't open for orders, yet.

DYS726 was discovered in a pericentomeric region of the ChrY that hasn't
been sequenced before Jan. 2005 by Kirsch et al. This region isn't
included in the current release of the human genome sequencing project
(HUGO). DYS726 seems to have some very long alleles (14 or 15) in E3b.
Most British based R1b males seem to have 12 repeats, but in Germany
many R1b males have 13.

The above markers (except DYS726) can be seen in NCBI mapviewer with the
following link:
*http://tinyurl.com/apsoa

Feel free to ask questions


Thomas

*
David Wilson wrote:

>Here's a question set for Thomas Krahn in particular, but I would welcome
>comment from others who may happen to have experience with these markers:
>
>On my DNA-FP results page are spaces to report results for DYS724, DYS725
>and DYS726. I recently tested 726 and got the value 12. I was thinking about
>ordering the other two just to have them.
>
>I don't see any of these markers listed on the current DNA-FP list of
>offered tests. Are they still in development, or can they be ordered now?
>
>Can Thomas or anyone tell me if these would be considered slow, medium, or
>fast mutators? I was wondering if they had any value by themselves or in
>combination to point to specific clades or subclades. I know that four
>months ago messages to the list suggested DYS725 (or coDYS464) might have
>potential value in making those kinds of distinctions. I don't think I ever
>saw anything about DYS724.
>
>David Wilson
>
>
>


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