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From:
Subject: Re: S21 Ancestral negative (was [DNA] I1a1 & DYS462)
Date: Sun, 23 Oct 2005 10:50:43 EDT
In a message dated 10/23/05 4:02:58 AM Pacific Daylight Time,
writes:
> Seems as if S21 negative (ancestral) and S21 positive (derived) makes more
>
> sense as I read the rest of the site. The above sounds as if one is
> negative
> for S21 ancestral and therefore derived, when my impression is that if one
> is
> negative for S21 one is ancestral instead of derived.. Or do I have this
> totally whacked in my mind? If so would David or someone please help me
> out of
> this blackhole I fell into?
The convention is to use the mutated allele as the point of reference. Thus
the derived version is positive for the mutation and the ancestral version is
negative for the mutation. (The ancestral version would be positive for the
ancestral allele and negative for the mutation, if you were using that frame of
reference, but we're not. I hope I said that right!)
Ann Turner
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