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Archiver > GENEALOGY-DNA > 2005-10 > 1130541586


From: <>
Subject: Re: [DNA] DYS 464 [infertility]
Date: Sat, 29 Oct 2005 00:19:46 +0100
References: <20.504352b7.30940656@aol.com>


Ann & List

here is a short paper about an interesting case of a father who managed to
pass on a large deletion (encompassing all the DAZ genes) to his two sons -
but they were both infertile.
http://jmg.bmjjournals.com/cgi/content/full/39/6/e27

Gareth


----- Original Message -----
From: <>
To: <>
Sent: Friday, October 28, 2005 11:55 PM
Subject: Re: [DNA] DYS 464 [infertility]


> In a message dated 10/28/05 1:21:10 PM Pacific Daylight Time,
> writes:
>
> > Concerning infertility and deletions at DYS 464:
> >
> > Do not be so confident that all men with deletions at DYS 464 are
> > infertile.
> >
> > I have only 15c and 16c at DYS 464, and I have two children that I am
sure
> >
> > I fathered.
>
> The question of infertility only arises in cases where DYS464 doesn't give
> you any readings at all, which may occur in about one out of two thousand
men or
> less. That can happen when a big chunk of the Y chromosome is deleted
(from
> memory, about 3 million bases). This chunk includes some genes involved in
> sperm production as well as DYS464, which doesn't code for anything
itself. There
> are multiple copies of the genes, so most men have backups -- if one copy
is
> missing or defective, you can use another copy. But if all of the backups
are
> missing, that is a known cause of infertility.
>
> Ann Turner



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