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Archiver > GENEALOGY-DNA > 2005-11 > 1132512469


From: "Ken Nordtvedt" <>
Subject: Re: [DNA] Haplogroup I questions
Date: Sun, 20 Nov 2005 11:47:49 -0700
References: <20051120173903.63434.qmail@web50701.mail.yahoo.com>


----- Original Message -----
From: "David Faux" <>
To: <>
Sent: Sunday, November 20, 2005 10:39 AM
Subject: Re: [DNA] Haplogroup I questions


For I1b we are now offering M395 (Ken can explain where this fits - it was
his recommendation that led to our developing the primers).

[Is this M395 or M359? Am I becoming dyslexic? KN]

>
> One thing that we must be careful about is the assumption that certain
> markers are phylogentically equivalent (one could be substituted for the
> other). We have a customer who tested P19+ with another company, and was
> then assigned M170+ to fit with the National Geographic Society
> Genographic Project requirements. The problem is that we found this
> fellow to be M170-

[When I suggested many weeks ago this person could conceivably be both P19+
and M170- with the SNPs being cleaved, you warned me on the list that I'm
flying in the face of all the academic authorities. So you have come
around? Also, this could be just lab error, or interface pronouncement
error between NGS/FTDNA, signifying nothing profound on what SNPs should be
performed in the bulk of the situations. KN]

The only way to know if you are M170+ (or any other SNP) is to test for it.
Have back mutations happened,

[So now you are suggesting people should buy otherwise noninformative SNPs
to check for conceivable back mutations? How far back; to genetic Adam?
KN]


Ken is calling for more Y-STR markers

[David, thank you, but I can describe myself what I am calling for, and it
includes a wide variety of SNPs when they will add information; I just don't
advise for the promiscuous measurements of SNPs because I know that will
soon discredit the whole enterprise and eventually make it harder to
convince people to even do the meaningful SNP tests. KN]


I am calling for more Y-SNP markers to be tested (I don't take a salary from
the firm I own so my motives are not financial).
>
> David Faux.


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