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Archiver > GENEALOGY-DNA > 2005-12 > 1135172317


From: "David Wilson" <>
Subject: RE: [DNA] Ethnoancestry Offers YSTR18 Haplotype Test
Date: Wed, 21 Dec 2005 05:38:37 -0800
In-Reply-To: <BAY102-F38F786B6BA81F7793387D5D53E0@phx.gbl>


Roxanne,

The RQMV2 haplotype has some differences in it that, in combination, set it
apart from the modal R1b haplotype over 37 markers. It stands at a genetic
distance of five from Modal R1b. Here's a comparison:

http://tinyurl.com/9nuvx

The differences occur at 390, 449, 464a, 460 and 570.

There are lots of matches at the 12-marker level, but that is because those
markers predominantly show the modal R1b values. And 390, while not modal,
shows a value that is not exactly rare in R1b.

In a collection of 4000+ R1b haplotypes, only a dozen and half show 449=28
AND 460=10. (David Faux knows one of them!) A couple have roots in Germany,
a couple more in Italy. Among those without specified European origins, the
surnames look sort of generally English -- maybe German, too, depending on
how you take Sanders.

The comparative evidence is way too thin to make a prediction, but I would
stay open to the possibility that your husband might turn out positive on
EA's S28 test. That's what David Faux is -- the only one in the public data
bases so far -- and you share the unusual 449/460 marker doublet with him.
To be sure, your husband also differs from the Faux haplotype at a couple of
places. That might point away from a possible positive test on S28. So it's
an open question.

I'm not advising the test, but I want you to be aware of it as a
possibility. In any event, your husband's haplotype is not as "plain
vanilla" as you originally thought.

David W.





-----Original Message-----
From: Roxanne Pendleton [mailto:]
Sent: Tuesday, December 20, 2005 1:12 PM
To:
Subject: Re: [DNA] Ethnoancestry Offers YSTR18 Haplotype Test

Yes, this is my husband's line and the Pendleton is my paternal line. My
husband is at Y search
RQMV2 Thank you for looking at it maybe there is something that would leap
out to someone else.


>From: "David Wilson" <>
>Reply-To:
>To:
>Subject: Re: [DNA] Ethnoancestry Offers YSTR18 Haplotype Test
>Date: Tue, 20 Dec 2005 06:10:45 -0800
>
>Roxanne,
>
>Just one point about differentiation: while one will always learn
>something from a panel of SNP tests, that doesn't mean you will always
>have an informative positive result in the package. Sometimes (as in my
>case so far), all the downstream SNPs will come back negative. That
>leaves me in haplogroup R1b1c* (or R1b3*, as we are using unofficial
>and official nomenclature systems simultaneously these days; whatever
>label you put on it, I am M269+).
>
>But remember that other people are getting SNP tests too. As some of
>them test positive on this SNP or that one, they and their kin are
>moved out of the undifferentiated collection. Today the R1b1c* clade
>is about 20 - 25% smaller than it was just six months ago, largely as a
>result of the new SNP tests offered by EthnoAncestry. As new SNPs are
>developed and people are tested for them, the "remainder" subclade
>becomes better defined by default.
>
>But I think there is a larger question you posed. If you are looking
>for matches to help with family history or finding possible kin among
>individuals with differing surnames, then you are better off ordering
>additional STRs than SNP refinements.
>
>There is a Pendleton haplotype in Ysearch (2YEUW), but that haplotype
>is unambiguously I1a. I take it this haplotype would reflect your
>paternal ancestry and is not your husband's results. Is his haplotype on
Ysearch?
>I'd
>be happy to take a look at it and tell you if anything jumps to my eye.
>You say his haplotype is modal at "almost every marker." But there may
>be something to be said about the ones where he differs.
>
>David Wilson
>Wilson Surname Project Co-Administrator
>
>
>
>On 12/19/2005 10:35:54 AM, Robert Stafford ()
>wrote:
> > A lot of R1bs only differ by a few markers from the modal. However,
> > in combination with the surname, 37 markers is more than sufficent.
> > Unless you have reason to believe that there is a false paternity,
> > you don't need to concern yourself with matches with other surnames.
> >
> > If he has a documented genealogy with gaps, it is possible that a
>fortuitous mutation might show up to tag his branch. However, this is
>really hit or miss and is expensive. I recommend this approach only
>after intitial deep testing of genealogies, so there will be enough
>donors to isolate the mutation.
> >
> > Bob Stafford
> >
> > Roxanne Pendleton <> wrote:
> > Perhaps you can give me some direction. I had my husband's DNA run
> > for 37 markers and found he is an Rb1 (M343). At almost every marker
> > his result is the same as the highest percentile of Rb1 people.
> > Nothing at all remarkable. Nothing. What if any, snps should I run
> > to differentiate him from the herd? Should I do additional markers
> > or snps? Curious.
> >
> >
> > >From: David Faux
> > >Reply-To:
> > >To:
> > >Subject: Re: [DNA] Ethnoancestry Offers YSTR18 Haplotype Test
> > >Date: Sat, 17 Dec 2005 0
>
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>
>==============================
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>

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