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From: "Roxanne Pendleton" <>
Subject: RE: [DNA] Ethnoancestry Offers YSTR18 Haplotype Test
Date: Wed, 21 Dec 2005 10:58:26 -0600
In-Reply-To: <20051221161550.71805.qmail@web50706.mail.yahoo.com>


Sorry, I should have changed the subject line but I was interested in if any
of the new snps would help my situation. Roxanne


>From: David Faux <>
>Reply-To:
>To:
>Subject: RE: [DNA] Ethnoancestry Offers YSTR18 Haplotype Test
>Date: Wed, 21 Dec 2005 08:15:50 -0800 (PST)
>
>A "sneaky way to advertise"! I can attest that neither of the individuals
>below have any financial link to EA nor anything to gain monetarily
>(neither do I for that matter because I do not take a salary) - so what
>pray tell are you talking about? They probably should have changed the
>subject line but this is a common thing. This is the second post of this
>nature in one week - the other one was also a misinterpretation.
>
> David Faux.
>
>Jon Spence <> wrote:
> What a sneaky way to advertise a service or product that requires
>payment for services rendered. I bring your attention to the subject line
>above. At what point is a peddler required to set up his/her own websites
>for advertising, pricing and in general, peddling items, instead of using a
>public domain? I thought that would be an an eBAY thing?
>
>WEBMASTER: Would you explain at what point you draw the line for
>advertising products on this website, aside from not allowing prices
>quotes?
>
>jon
>
>
>
>David Wilson wrote:
>Roxanne,
>
>The RQMV2 haplotype has some differences in it that, in combination, set it
>apart from the modal R1b haplotype over 37 markers. It stands at a genetic
>distance of five from Modal R1b. Here's a comparison:
>
>http://tinyurl.com/9nuvx
>
>The differences occur at 390, 449, 464a, 460 and 570.
>
>There are lots of matches at the 12-marker level, but that is because those
>markers predominantly show the modal R1b values. And 390, while not modal,
>shows a value that is not exactly rare in R1b.
>
>In a collection of 4000+ R1b haplotypes, only a dozen and half show 449=28
>AND 460=10. (David Faux knows one of them!) A couple have roots in Germany,
>a couple more in Italy. Among those without specified European origins, the
>surnames look sort of generally English -- maybe German, too, depending on
>how you take Sanders.
>
>The comparative evidence is way too thin to make a prediction, but I would
>stay open to the possibility that your husband might turn out positive on
>EA's S28 test. That's what David Faux is -- the only one in the public data
>bases so far -- and you share the unusual 449/460 marker doublet with him.
>To be sure, your husband also differs from the Faux haplotype at a couple
>of
>places. That might point away from a possible positive test on S28. So it's
>an open question.
>
>I'm not advising the test, but I want you to be aware of it as a
>possibility. In any event, your husband's haplotype is not as "plain
>vanilla" as you originally thought.
>
>David W.
>
>
>
>
>
>-----Original Message-----
>From: Roxanne Pendleton [mailto:]
>Sent: Tuesday, December 20, 2005 1:12 PM
>To:
>Subject: Re: [DNA] Ethnoancestry Offers YSTR18 Haplotype Test
>
>Yes, this is my husband's line and the Pendleton is my paternal line. My
>husband is at Y search
>RQMV2 Thank you for looking at it maybe there is something that would leap
>out to someone else.
>
>
> >From: "David Wilson"
> >Reply-To:
> >To:
> >Subject: Re: [DNA] Ethnoancestry Offers YSTR18 Haplotype Test
> >Date: Tue, 20 Dec 2005 06:10:45 -0800
> >
> >Roxanne,
> >
> >Just one point about differentiation: while one will always learn
> >something from a panel of SNP tests, that doesn't mean you will always
> >have an informative positive result in the package. Sometimes (as in my
> >case so far), all the downstream SNPs will come back negative. That
> >leaves me in haplogroup R1b1c* (or R1b3*, as we are using unofficial
> >and official nomenclature systems simultaneously these days; whatever
> >label you put on it, I am M269+).
> >
> >But remember that other people are getting SNP tests too. As some of
> >them test positive on this SNP or that one, they and their kin are
> >moved out of the undifferentiated collection. Today the R1b1c* clade
> >is about 20 - 25% smaller than it was just six months ago, largely as a
> >result of the new SNP tests offered by EthnoAncestry. As new SNPs are
> >developed and people are tested for them, the "remainder" subclade
> >becomes better defined by default.
> >
> >But I think there is a larger question you posed. If you are looking
> >for matches to help with family history or finding possible kin among
> >individuals with differing surnames, then you are better off ordering
> >additional STRs than SNP refinements.
> >
> >There is a Pendleton haplotype in Ysearch (2YEUW), but that haplotype
> >is unambiguously I1a. I take it this haplotype would reflect your
> >paternal ancestry and is not your husband's results. Is his haplotype on
>Ysearch?
> >I'd
> >be happy to take a look at it and tell you if anything jumps to my eye.
> >You say his haplotype is modal at "almost every marker." But there may
> >be something to be said about the ones where he differs.
> >
> >David Wilson
> >Wilson Surname Project Co-Administrator
> >
> >
> >
> >On 12/19/2005 10:35:54 AM, Robert Stafford ()
> >wrote:
> > > A lot of R1bs only differ by a few markers from the modal. However,
> > > in combination with the surname, 37 markers is more than sufficent.
> > > Unless you have reason to believe that there is a false paternity,
> > > you don't need to concern yourself with matches with other surnames.
> > >
> > > If he has a documented genealogy with gaps, it is possible that a
> >fortuitous mutation might show up to tag his branch. However, this is
> >really hit or miss and is expensive. I recommend this approach only
> >after intitial deep testing of genealogies, so there will be enough
> >donors to isolate the mutation.
> > >
> > > Bob Stafford
> > >
> > > Roxanne Pendleton wrote:
> > > Perhaps you can give me some direction. I had my husband's DNA run
> > > for 37 markers and found he is an Rb1 (M343). At almost every marker
> > > his result is the same as the highest percentile of Rb1 people.
> > > Nothing at all remarkable. Nothing. What if any, snps should I run
> > > to differentiate him from the herd? Should I do additional markers
> > > or snps? Curious.
> > >
> > >
> > > >From: David Faux
> > > >Reply-To:
> > > >To:
> > > >Subject: Re: [DNA] Ethnoancestry Offers YSTR18 Haplotype Test
> > > >Date: Sat, 17 Dec 2005 0
> >
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