GENEALOGY-DNA-L ArchivesArchiver > GENEALOGY-DNA > 2006-01 > 1136578485
From: Thomas Krahn <>
Subject: Re: [DNA] YCA iib mutations: infinite alleal
Date: Fri, 06 Jan 2006 21:14:45 +0100
Mark MacDonald wrote:
>Thanks Thomas, so will it take about $80 to get you my cousin's cheek swab
>tested for just YCA?
I didn't say that it is necessary to take another test. RecLOH is not a
test but a phenomenon that we can observe in nature.
If you observe such a strange jump in STR alleles at duplicated markers,
you can believe, that it is a multistep frame shift mutation or you can
accept my suggestion of a recombination event. There is probably no need
to re-test YCAII, because another laboratory would probably get the same
If you want to have a further proof or an evidence against a recLOH
event, you can better have a look at the DYF371 marker, that is located
on the same palindrome (P5) as YCAII. If the theory of linked recLOH
events is correct, we should observe a recLOH at DYF371 as well.
A recLOH is only an explanation of what might have happened in the near
past that makes us observing "long-jumps" at the alleles of duplicated
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