GENEALOGY-DNA-L ArchivesArchiver > GENEALOGY-DNA > 2006-02 > 1139919379
From: VALERY <>
Subject: Re: [DNA] Haplogroup N1 versus A2 versus D3
Date: Tue, 14 Feb 2006 15:16:19 +0300
George, it seems that they complicated the issue a bit. Although RFLP check
for A would be helpful, in this case it's not the only one way to find out
what the haplogroup is.
First of all, the sequence is quite far off from being in N1c, because all
N1c have transition at 265, not the transversion! 265T is quite rare
outside L3e3 haplogroup, though does exist. Considering your other
differences from the CRS, the first and most "parsimonious" decision is A.
There is one match from SWGDAM, this sample was taken from a Hispanic
(HVS1 16024-16365; HVS2 73-340)
HVS2 places this lineage in A2. I'd say, it's near a perfect HVS1 match.
Thus, having been resolved, this lineage would predict your own haplogroup:
such a non-trivial coincidence serves as more weighty evidence of your
being in A haplogroup than any RFLPs. It remains to prove that:
1) HVS2 from SWGDAM belongs to the same individual as HVS1; There is no
problem here - you may get your own HVS2 sequence.
2) SWGDAM HVS1 sequence is correct, i.e. there are no repeatable conditions
(PCR, biochemical etc) when some sites cause the occurence of phantom
mutations. I do emphasize - repeatable, since you share near the same set of
mutations with the SWGDAM individual. This is a really complicated problem,
though might be solved by resequencing.
|Re: [DNA] Haplogroup N1 versus A2 versus D3 by VALERY <>|