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Archiver > GENEALOGY-DNA > 2006-03 > 1141540138


From: "John McEwan" <>
Subject: RE: [DNA] Ui Neill Irish Lineage SNP Located
Date: Sun, 5 Mar 2006 19:28:58 +1300
In-Reply-To: <20060305024348.46485.qmail@web50704.mail.yahoo.com>


Dear List

I think congratulations are in order to those involved in associating
M222 to the Irish Modal haplotype and to also at this early stage
resolving it to a likely sister clade within R1b1c. The SNP will be very
useful to both genealogists and anthrogenealogy.

The US studies estimated M222+ was ~2% of the groups studied, which had
a good dash of Irish in them.

In Ysearch at its widest definition the associated STR cluster
(R1bSTR19Irish) is 184 individuals out of 3995 or 5% (mostly US donors)
and 184/2552 or 7.2% of R1b. The figures are 64/422 of those listing
Irish origin (15.2%) and 64/323 (19.8%) of R1b for those from Ireland.

As David Faux says it will be extremely interesting associating M222
with the R1b STR clusters. My hope is that it occurred either before or
after R1bSTR19Irish (Irish modal haplotype) expanded, because that will
provide far more information than simply mirroring this well defined
existing cluster. In the best of worlds it would have happened BEFORE as
this may drag in more of the original indigenous hunter gatherer
inhabitants of Ireland and Britain after the LGM. Existing STR based
methods would struggle in this area.

If we conservatively say it is just mirrors the cluster then we have
another 7% of R1b1c positively classified by SNPs. Along with S21, S28,
SRY2627 (currently 39% are derived for one of these SNPs based on the
R1b SNP summary page) and hopefully soon S25 (estimated as ~9% of non
R1bSTR19Irish, R1bSTR22 and R1bSTR47Scots) we are up to 55% derived for
a specific SNP. If we then add R1bSTR47Scots as a well defined STR
cluster to this mix we add 133/2552 (5.2%) and we breach 60%.

This has all happened in the last year!

We live in interesting times.

Again congratulations

Cheers

John McEwan


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