GENEALOGY-DNA-L Archives

Archiver > GENEALOGY-DNA > 2006-05 > 1146623197


From: ellen Levy <>
Subject: Re: [DNA] Haemochromatosis and R1b was TMRCA interpretation, was
Date: Tue, 2 May 2006 19:26:37 -0700 (PDT)
In-Reply-To: <00bc01c66e2a$8c287020$0101a8c0@your447023ae6b>


List:

I'm going to reiterate again from the R1b thread that
I participated in last month: There is no genetic
evidence that R1b (WAMH)along the Atlantic seaboard
dates to the Paleolithic and, in fact, the evidence
that does exist (particularly aDNA studies) indicates
that it may date to the Neolithic or later. I realize
the topic is Hemochromatosis, but I'll refer readers
to the thread last month concerning the issue of
whether the first inhabitants of the British Isles
were "Celts" and R1b. The Celtic languages did not
even arise until approximately 3000-4000 years ago.
Thus, the Paleolithic inhabitants of the British
Isles, whomever they were, were not speaking the
Celtic tongue (or probably any Indo-European language,
for that matter). More importantly, the assumption
that the genetic structure of contemporary populations
is reflective of that which existed in prehistoric
populations is potentially highly misleading, as
indicated by the aDNA studies on mtDNA.

The Basques, who have the highest frequency of R1b
among any Europeans, have the lowest frequency of
hemochromatosis, while the Celtic populations (who are
supposedly their closest R1b cousins) have the
highest. Please refer to the list thread of Dec 8,
2004 on this topic, including the 2001 paper by F.
Bauduer entitled "Genetic Hemochromatosis is a Rare
Disease Entity among French Basques: A Center-Based
Study from the General Hospital of Basque Country."

Gerard Lucotte, in his study, "Celtic Origin of the
C282Y Mutation of Hemochromatosis," found that the low
frequency of the C282Y allele in Basques "confirms
that it is highly improbable that this mutation is of
ancient European origin."

Ellen Coffman




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