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Archiver > GENEALOGY-DNA > 2006-05 > 1146683408


From: "Daniel Jenkins" <>
Subject: Re: [DNA] Haemochromatosis and R1b and Plague
Date: Wed, 03 May 2006 19:10:08 +0000
In-Reply-To: <004401c66edc$e3f98980$6401a8c0@charlie1>


Janet ,

I don't know about the jaundice but will look for info. I do know that there
is a certain skin pigmentation that is present with the disease . I saw a
photo at a site that I can't recall. It is a kind of mottling small light
and dark spots, but not freckles.

Dan Jenkins


>From: "ljcrain" <>
>Reply-To:
>To:
>Subject: Re: [DNA] Haemochromatosis and R1b and Plague
>Date: Wed, 3 May 2006 13:10:41 -0500
>
>Can someone tell me if jaundice is always present with hemochromatosis? My
>red headed father had a ruddy complexion and always said giving blood made
>him feel better. I wonder about that. I wanted my husband to be tested, but
>his cardiologist refused saying he would be jaundiced if he had the
>condition. I couldn't find the answer to this in any online sites about
>hemochromatosis.
>
>Thanks.
>
>Janet Crain
>
>
>----- Original Message ----- From: "John Abernethy" <>
>To: <>
>Sent: Wednesday, May 03, 2006 10:09 AM
>Subject: Re: [DNA] Haemochromatosis and R1b and Plague
>
>
>>My gratitude for the erudition of Ellen, Daniel and the
>>quinntessential Brian!. Brian's hypothesis of hemochromatosis
>>conferring protection against bubonic plague has explanatory power but
>>is there any hard evidence for this mechanism?.
>>I noted with interest that Belfast in County Antrim had a prevalence
>>of 9.9 % of the C282Y mutation, second only to Dublin (14.2%). My
>>ggg-grandfather John Abernethy lived in Antrim. (For what it is worth
>>the only John Abernethy that I ever met was from Belfast).
>>
>>Daniel: Even as a heterozygote you can certainly attest to the
>>morbidity of hemochromatosis and are to be congratulated in your
>>crusade to alert others. Serum ferritin levels should be high on the
>>list of routine blood tests that doctors perform but that ain't
>>necessarily so. Being heterozygous (at least for the C282Y mutation)
>>may also be deleterious in terms of longevity (Bathum et al. Arch
>>Intern Med 2001 Nov 12;161(20):2441-4.)
>>
>>Many thanks
>>--
>>John Abernethy
>>
>>______________________________
>
>
>
>==============================
>Census images 1901, 1891, 1881 and 1871, plus so much more.
>Ancestry.com's United Kingdom & Ireland Collection. Learn more:
>http://www.ancestry.com/s13968/rd.ashx
>

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