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Archiver > GENEALOGY-DNA > 2006-05 > 1146691257


From: "ljcrain" <>
Subject: Re: [DNA] Haemochromatosis and R1b and Plague
Date: Wed, 3 May 2006 16:20:57 -0500
References: <BAY107-F284C166CC463BBBE0CD43E85B70@phx.gbl>


Thank you, Dan!

Janet


----- Original Message -----
From: "Daniel Jenkins" <>
To: <>
Sent: Wednesday, May 03, 2006 2:10 PM
Subject: Re: [DNA] Haemochromatosis and R1b and Plague


> Janet ,
>
> I don't know about the jaundice but will look for info. I do know that
> there is a certain skin pigmentation that is present with the disease . I
> saw a photo at a site that I can't recall. It is a kind of mottling small
> light and dark spots, but not freckles.
>
> Dan Jenkins
>
>
>>From: "ljcrain" <>
>>Reply-To:
>>To:
>>Subject: Re: [DNA] Haemochromatosis and R1b and Plague
>>Date: Wed, 3 May 2006 13:10:41 -0500
>>
>>Can someone tell me if jaundice is always present with hemochromatosis? My
>>red headed father had a ruddy complexion and always said giving blood made
>>him feel better. I wonder about that. I wanted my husband to be tested,
>>but his cardiologist refused saying he would be jaundiced if he had the
>>condition. I couldn't find the answer to this in any online sites about
>>hemochromatosis.
>>
>>Thanks.
>>
>>Janet Crain
>>
>>
>>----- Original Message ----- From: "John Abernethy" <>
>>To: <>
>>Sent: Wednesday, May 03, 2006 10:09 AM
>>Subject: Re: [DNA] Haemochromatosis and R1b and Plague
>>
>>
>>>My gratitude for the erudition of Ellen, Daniel and the
>>>quinntessential Brian!. Brian's hypothesis of hemochromatosis
>>>conferring protection against bubonic plague has explanatory power but
>>>is there any hard evidence for this mechanism?.
>>>I noted with interest that Belfast in County Antrim had a prevalence
>>>of 9.9 % of the C282Y mutation, second only to Dublin (14.2%). My
>>>ggg-grandfather John Abernethy lived in Antrim. (For what it is worth
>>>the only John Abernethy that I ever met was from Belfast).
>>>
>>>Daniel: Even as a heterozygote you can certainly attest to the
>>>morbidity of hemochromatosis and are to be congratulated in your
>>>crusade to alert others. Serum ferritin levels should be high on the
>>>list of routine blood tests that doctors perform but that ain't
>>>necessarily so. Being heterozygous (at least for the C282Y mutation)
>>>may also be deleterious in terms of longevity (Bathum et al. Arch
>>>Intern Med 2001 Nov 12;161(20):2441-4.)
>>>
>>>Many thanks
>>>--
>>>John Abernethy
>>>
>>>______________________________
>>
>>
>>
>>==============================
>>Census images 1901, 1891, 1881 and 1871, plus so much more.
>>Ancestry.com's United Kingdom & Ireland Collection. Learn more:
>>http://www.ancestry.com/s13968/rd.ashx
>>
>
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