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Archiver > GENEALOGY-DNA > 2006-05 > 1147123576


From: "Alfred A. Aburto Jr." <>
Subject: Re: [DNA] Haemochromatosis and R1b was TMRCA interpretation, was
Date: Mon, 08 May 2006 14:26:16 -0700
References: <027801c672e1$5d128260$0101a8c0@HighReaches.local>
In-Reply-To: <027801c672e1$5d128260$0101a8c0@HighReaches.local>


The article indicated "Caucasians and other ethnic groups". Interesting!
I'm J2a and diabetic. I think I'll ask my doctor about hemochromatosis.
Al


> Glen Todd wrote:

>People;
>
>After reading the Diabetes.org site, this has suddenly caught my attention.
>
>Is hemochromatosis solely associated with R1b, or does it show up in other
>Western European populations?
>
>Glen
>
>
>
>>John:
>>
>>Sorry I wasn't able to respond earlier. A little busy last week. Here
>>is some information from the American Diabetes Association:
>>
>>"Hereditary hemochromatosis represents a striking example of the
>>"founder effect," which describes a genetic disease that arises from a
>>mutation in just one or a few individuals. In the case of
>>hemochromatosis, it is believed that a single individual in Europe, 60
>>to 70 generations ago, was the sole origin of most of the
>>hemochromatosis seen in the world today. A chance mutation in the HFE
>>gene in this individual was passed on, and because the defective gene
>>didn't cause any problems in people through child-bearing age (and may
>>have conferred some benefit in times of nutritional deficit), there
>>was no negative selection to stop it from being passed on. Because of
>>its origin, hemochromatosis today most often affects Caucasians of
>>Northern European descent, although other ethnic groups can be
>>affected by other iron overload diseases."
>>
>>http://www.diabetes.org/type-1-diabetes/hemochromatosis.jsp
>>
>>60 to 70 generations ago would mean that the gene was less
>>than 2,000 years old.
>>
>>Regards,
>>
>>Paul D.
>>
>>
>>On 5/2/06, John Abernethy <> wrote:
>>
>>
>>>On 5/2/06, Havelock Vetinari <> wrote:
>>>
>>>As a predicted R1b (SNPs pending) and probable carrier of the C282Y
>>>gene (my sister has an elevated serum iron, mine is normal), I am
>>>interested in your evidence that hemochromatosis is less than 2000
>>>years old.
>>>
>>>Thanks
>>>--
>>>John Abernethy.
>>>Ybase LZJJ6
>>>
>>>

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