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Archiver > GENEALOGY-DNA > 2006-06 > 1149607204


From: "William Hurst" <>
Subject: RE: [DNA] Re: Three mtDNA K charts
Date: Tue, 06 Jun 2006 11:20:04 -0400
In-Reply-To: <448585D8.7010604@worldnet.att.net>


Jim wrote:
>
>Lee Anne,
>
>Thanks for contributing that information.
>
>I am intrigued by the similarity between my case (first line) and yours
>(second line):
>
>048A,093C,224C,291T,311C,519C 73G,195C,263G,315.1C,497T,524.1C,524.2A
>
>048A,093C,224C,291T,311C,519C
>73G,195C,263G,315.1C,497T,524.1C,524.2A,524.3C,524.4A
...............
>In summary, unless those last two mutations 524.3C,524.4A are of major
>significance, the mtDNA points to a common origin for both cases, and my
>family history points to English settlers in County Limerick. But other
>matches to my case don't point to ancient Irish roots or to England for the
>maternal line. They indicate the origin of my maternal line was Norse.

Hi Jim and Lee Anne and all,

First, as I have discussed before, the 524.3C and 524.4A insertions in the
second haplotype are always paired, so I count them as one mutation. In a
recent posting, I worked out that in the approximately 16,000 years since
the origin of K, the average number of years between mutations is about
4000. Beyond the basic six mutations for K, the first haplotype has 16048A,
16093C, 16291T, 195C, 497T, and the paired 524.1C and 524.2A. So that looks
like 24,000 years worth of mutations, which is obviously not right. 16093C,
195C and the 524 insertions are considered recurrent mutations, so maybe
they should not be given full weight in the timescale.

Although none of the mutations is especially rare, the combination is fairly
rare, and with a real genetic distance of one; you two no doubt share a
common ancestor much more recent than the original K. But that still might
have been before the adoption of surnames. Or it could have happened in the
last generation. I think my chart of the 524 insertions shows that there is
no way to tell how much time is required between the first and second pair.
It appears that other mutations often occur in between.

How this helps, instead of confusing you more.

Bill Hurst


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