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Subject: Re: [DNA] New S25 results from EA
Date: Thu, 15 Jun 2006 22:04:20 -0700


"The time has come," the Walrus said,
"To talk of many things..."

> I'll look forward to whatever the R1b crowd can tell me about the
> possible significance of this. I hope a lot more people will be tested
> for S25, so we can see whether it's universal in R1b, or what.
>
> Oh yeah, though S25 has been associated with a null 463 (according to
> what I read), Tom has been found to have a value of 24 there by DNA-F,
> which would be 22 in the nomenclature used elsewhere.


Hi, Bonnie. I have been pretty inactive for some months now,
preoccupied with rekindling an old flame :-) I'm one of the three
S25+ results currently listed in John McEwan's R1b subclade database.
I have kept abreast of progress on this SNP since it's inception late
last year & up to the present. I am indeed a DYS 463 null on the SMGF
database, but not with Relative Genetics, which also uses the
Sorenson lab. It may be that Sorenson quickly adjusted their primers
when they continued to get nulls on that STR, but that's just a best
guess. What's more important is that Wilson & Faux now believe that
the S25 may be a very old SNP, & near universal in R1b, much like P25
or M269. The three of us that tested early had reason to believe that
it might have been a good subclade marker for us, so we paid for the
test when it was offered.

I addressed some of these issues in a thread started last month on 9
May 2006, with subject line "M37 & P66 failures". David Faux picked
it up & retitled the thread "M37 and P66 failures + R1b - S25
Update". It can be reviewed in the Rootsweb Archives. The gist of it
is that perhaps all R1bs will be S25+. David suggested at that time
that EA would be testing a number of diverse R1b haplotypes to
determine if this is the case. Your friend's results suggest that
this may be part of that process. It is beginning to look like that
it is indeed the case. That said, you will note from John McEwan's
list that not all M269+ results are P25+ & vice versa, so it is still
a worthwhile SNP to add to the arsenal. Hope this helps. Pat Tagert




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