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Subject: PubMed abstract: Y-STRs in the Iberian Peninsula
Date: Fri, 23 Jun 2006 12:44:24 EDT


Am J Hum Biol. 2006 Jun 20;18(4):532-539 [Epub ahead of print]

Gene flow in the Iberian Peninsula determined from Y-chromosome STR loci.

Pena JA, Garcia-Obregon S, Perez-Miranda AM, De Pancorbo MM, Alfonso-Sanchez
MA.

Departamento de Genetica, Antropologia Fisica y Fisiologia Animal,
Universidad del Pais Vasco, 48080 Bilbao, Spain.

In this work, seven multiallelic short-tandem repeat (STR) loci from the
nonrecombining region of the human Y-chromosome (DYS19, DYS389 I, DYS389 II,
DYS390, DYS391, DYS392, and DYS393) were typed in a sample of residents in the
Basque Country (RBAS). In all, 40 different Y-STR haplotypic combinations were
identified, resulting in a value of haplotypic diversity of 0.979. Y-STR data
compiled from previous works were used for studying Y-chromosome diversity in the
Iberian Peninsula and for assessing the effects of migratory movements on the
genetic background of the population living currently in territories
traditionally occupied by native (autochthonous) Basques. An analysis of the spatial
distribution of allelic frequencies of the Y-STRs revealed a geographic pattern
characterized by variation gradients (frequency clines) oriented for the most
part in the direction southwest-northeast. Accordingly, a neighbor-joining
analysis showed a relative polarization between populations located in the
northeast and center of the Iberian Peninsula, and the rest of the samples
considered. The study sample (RBAS) occupied an intermediate position in the
population tree between the autochthonous Basques (BASQ) and the remaining samples.
Interestingly, the RBAS collection only showed genetic heterogeneity with that of
native Basques (Phi(ST) = 0.013, P < 0.05). Estimates of admixture
proportions in the gene pool of RBAS indicated a high level of hybridization with Basque
(56%) and non-Basque (44%) genes, which could explain the genetic
differentiation observed between BASQ and RBAS. Am. J. Hum. Biol. 18:532-539, 2006. (c)
2006 Wiley-Liss, Inc.

PMID: 16788906 [PubMed - as supplied by publisher]


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