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Archiver > GENEALOGY-DNA > 2006-08 > 1155355966


From: "Ron Scott" <>
Subject: Re: [DNA] Matching
Date: Fri, 11 Aug 2006 23:12:46 -0500
References: <235.dc0c8ea.320d9e4e@aol.com>


Ann,

Thanks for the info. I was also curious if there have been any reports of
differences between father-son pairs in the so-called "nonmutated alleles"
DYS392, 393 and YCAII a/b since the Kayser paper in 2000. Or, perhaps, do
you know the number of generations before mutations might occur in
transmission?

BTW, the mitoSearch mutation spreadsheet for HVR1 is nearly complete, with
only a couple more hgs to analyze. When done, you'll be the first to see
it.

Ron

----- Original Message -----
From: <>
To: <>
Sent: Friday, August 11, 2006 3:48 AM
Subject: Re: [DNA] Matching


> In a message dated 8/10/2006 9:15:35 PM Pacific Daylight Time,
> writes:
>
>> I'm not clear why mutation rates should be different outside father-son
>> rates. Please explain.
>
> FTDNA bases their rates on an in-house study of pedigrees submitted by
> surname project administrators, who were solicited explicitly to
> participate in a
> study on mutation rates.
>
>
> http://web.archive.org/web/20041009224127/http://www.familytreedna.com/mutation_study.html
>
> Later, there was an open announcement about the study
>
> http://www.familytreedna.com/facts_genes.asp?act=show&nk=2.10
>
> My best guess is that the final submissions were not a random sample. I
> can
> easily imagine how projects with no (or few) mutations might think their
> data
> wouldn't be interesting for a study on mutation rates. This sort of
> response
> bias would be difficult to control in a study relying on volunteers, who
> undoubtedly had to spend quite a bit of time preparing their descendancy
> charts in a
> form where transmission events could be counted. There have been no formal
> publications outlining methods, however, so that's just my take on it.
>
> Ann Turner
>


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