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Archiver > GENEALOGY-DNA > 2006-08 > 1155602740


From: "Ken Nordtvedt" <>
Subject: Re: [DNA] Null value at DYS425
Date: Mon, 14 Aug 2006 18:45:40 -0600
References: <44E11608.9010805@comcast.net>


Is DYF371 on the same palindrome as any of the more common multi-copy
markers, such as YCA, etc.?

Ken
----- Original Message -----
From: "Bonnie Schrack" <>
To: <>
Sent: Monday, August 14, 2006 6:32 PM
Subject: RE: [DNA] Null value at DYS425


>
> Was ist los?

Well, so far anyway, we still have our DYS425 values in the J project.
But just now, we got a new result for a J2a1* participant -- he has a
null at that marker.

Ohhh! It works fine in Firefox -- it's with IE that the blanks occur for
DYS425. If you all will check out your results tables with Firefox, I
bet you will find everything in order. My Firefox version has all the
normal values, plus the person with a null has a 0 with two red
asterisks: ** They're a link to the message,

> ****A value of “0” for any marker indicates that the lab reported a null
> value or no result for this marker. All cases of this nature are retested
> multiple times by the lab to confirm their accuracy. Mutations causing
> null values are infrequent, but are passed on to offspring just like other
> mutations, so related male lineages such as a father and son would likely
> share any null values.

So it looks as though they just need to fix the web pages to function in
IE. Maybe there is just a little time lag in implementing that.

This DYS425 marker is actually one of the four copies of the palindromic
marker, DYF371. It's the one with a T; the other three copies (normally
three, but sometimes more), have a C.

When there is a RecLOH event, one of the C copies is copied over onto
the T copy. When there is no longer a T copy, the primer for DYS425
doesn't pick it up, and we get a null result.

I'm also in touch with a group of related J2a1b1 (J2f1) families, in
which two have been tested for DYF371, and they show this same
situation, where all the (five) copies are C.
Hope this is helpful.

Bonnie


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