GENEALOGY-DNA-L Archives

From: Jim T <>
Subject: Re: [DNA] EA 18 STR Panel- Marker DYS575 (Alister John Marsh)
Date: Sun, 1 Oct 2006 08:49:43 -0700 (PDT)
In-Reply-To: <mailman.531.1159686263.32419.genealogy-dna@rootsweb.com>

I'd like to add my plea for three of the very slow
DNA-Fingerprint markers that will soon be available from FTDNA,
DYS716, DYS717, and DYF371. The odds of being non-modal on any
one of these is small, but about 40% of men will be non-modal on
at least one of them. I understand that FTDNA customers will
soon be able to order these markers individually at a low cost.

Jim Turner


John wrote:
>
> List,
>
>
>
> A PLEA FOR MORE TESTING OF POTENTIALLY INTERESTING MARKER
> DYS575:
>
>
>
> I have made no secret on this list of my interest in the very
> slow mutating
> STR markers ("baby SNPs"). Several of the very slow mutating
> markers are
> looking to be useful for families I am researching, where rare
> off modal
> values are encountered.
>
>
>
> Some of the very slow mutating markers seem to have mutated
> very rarely
> within haplogroups. If a rare mutation has occurred early in
> a haplogroup,
> it has the potential to divide a haplogroup largely into two
> equal related
> groups, but if it has occurred very late in the haplogroup, it
> might signify
> only a very small subclade.
>
>
>
> One apparently slow marker, is DYS575, which is currently only
> tested by
> Ethnoancestry. Only just over 40 results have been shown on
> public
> databases for this marker. Results I have seen include the
> following
> haplogroups. R1b1c, R1b1c6, R1b1c7, R1b1c9, R1b1c10, R1a, I1a,
> I1b, G2,
> J2a1, E3b1. All of these have DYS575=10, except for one
> R1b1c which has 9,
> and 1 R1b1c which has 11. Although 40 results is a
> statistically small
> group, it is interesting that DYS575=10 is universal outside
> of R1b1c to
> date. This implies a very slow mutation rate. Markers with
> low allele
> values, such as 10 tend to be slower mutators, and that also
> may be an
> indicator of a very slow mutating marker.
>
>
>
> What interests me about DYS575, is that of 18 R1bs tested for
> the marker,
> the two off modal results of 9 and 11 might potentially be
> hinting at
> something useful. These off modal results are not in any of
> the larger
> identified subclades of R1b1c6, R1b1c7, R1b1c9, R1b1c10, but
> in
> undifferentiated R1b1c. If hypothetically, mutations to
> either 9 or 11 had
> occurred high enough up the R1b1c tree to include 5% or more
> of R1b1c, then
> they may be a good indicator of what effectively is a sizable
> R1b1c
> subclade. If that is the case, it might be useful to help
> trace early
> ancestral origins of off modal persons.
>
>
>
> In the case of DYS641, of about 200 R1bs on the R1b project,
> all are
> DYS641=10, except for one result which is DYS641=11. From
> this it is
> inferred that DYS641 is very slow mutating, but also, because
> off modal
> scores of 11 are so rare, they are only useful to a small
> number of people,
> perhaps 0.5% of R1b. But in the case of DYS575, we have so
> few results,
> only about 18 R1bs, that we don't yet know if off modal scores
> of 9 and 11
> might be represented in 0.5%, or 5%, or 20% of
> undifferentiated R1b1c. As
> only about 18 R1bs have published results for this marker, it
> could be
> looked at as largely "unexplored territory".
>
>
>
> My plea to those that can afford it, is to help us explore
> DYS575, and get a
> few more results on record. For those who have already tested
> this marker,
> but don't have it on databases, I encourage you to put it on
> Y-Search, which
> now accommodates this marker. On a personal level, as I am
> R1b1c with
> DYS575=9, I would be interested to hear from any R1bs tested
> who have a
> result of 9. I am feeling a bit lonely, as the only person
> tested in any
> haplogroup with a result of 9, on any public database.
>
>
>
> I note that the EA panel of 18 STRs, includes quite a few more
> markers
> tested only by EA, so testing this panel might find more of
> interest for
> customers, other than just the results for DYS575.
>
>
>
> John.



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This thread:

• [DNA] EA 18 STR Panel- Marker DYS575 by "Alister John Marsh" <>
  • Re: [DNA] EA 18 STR Panel- Marker DYS575 by "rjhaskins" <>
  • Re: [DNA] EA 18 STR Panel- Marker DYS575 by "Ron Scott" <>
    • Re: [DNA] EA 18 STR Panel- Marker DYS575 by "Alister John Marsh" <>

  • Re: [DNA] EA 18 STR Panel- Marker DYS575 (Alister John Marsh) by Jim T <>