GENEALOGY-DNA-L ArchivesArchiver > GENEALOGY-DNA > 2006-10 > 1159804974
From: "Alfred A. Aburto Jr." <>
Subject: Re: [DNA] MLE
Date: Mon, 02 Oct 2006 09:02:54 -0700
> Chris wrote:
>I note several sites ie smgf give MLE's. ie most likely estimate. How is this calculated please (please note I'm no mathematician).
The MLE (Maximum Likelihood Estimate as it is called), in generations,
is determined by:
MLE = ln(n/k) / (2*mu)
"ln" is the symbol for "natural logorithm"
"n" is the number of markers
"k" is the number of markers whose values match.
"mu" is the mutation rate in generations (generally a nominal value of
0.002 is used).
It looks like the mutation rate used at SMGF depends upon the markers
could work this out though by looking at 1 marker mismatch cases (I
haven't done it).
On SMGF if you have a 36/37 match (k=36, n=37) then the
MLE = ln(37/36)/(0.004) ~ 6.8 generations (round to 7).
On SMGF DYS464 is not counted for the TMRCA estimates.
|Re: [DNA] MLE by "Alfred A. Aburto Jr." <>|