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Archiver > GENEALOGY-DNA > 2006-11 > 1163348250


From: Vincent Vizachero <>
Subject: Re: [DNA] Conference [recLOH]
Date: Sun, 12 Nov 2006 10:17:30 -0600
References: <539.c7d7c43.32821267@aol.com> <455744E3.8030506@earthlink.net>
In-Reply-To: <455744E3.8030506@earthlink.net>


On Nov 12, 2006, at 9:59 AM, Adrian Williams wrote:

> I hope this clears my earlier confusion. There is some additional
> information about DYS464 and how it can exist on two different
> arms, but that is another discussion for another day. If someone
> can help clarify and/or correct this, I know I for one will be
> grateful as I was still in the "oh crap!" mindset when some of this
> was being explained during Thomas' presentation.

I would only add the following, based on my recollection and
understanding:

1. There are two possible configurations of P1 and P2. They can
exist separately or combine into a single palindrome arm (P1/P2),
thereby raising the number of possible solutions.

2. Palindromic regions do not always manifest as palindromic arms,
which is one reason that sometimes you can get a RecLOH and sometimes
just normal mutations.

3. The parsimony principle dictates that you establish the minimal
number of steps that can explain your results. For example a
mutation at DYS385 from 11,15 to 11,12 should be counted as a GD of
2, not 3. The most parsimonious explanation is a RecLOH (the 15
became 11) followed by a normal mutation (one of the 11s became a 12).

Vince

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