GENEALOGY-DNA-L ArchivesArchiver > GENEALOGY-DNA > 2006-11 > 1164023826
From: Gary Felix <>
Subject: Re: [DNA] mtDNA Haplogroup C exact HVR1 match.
Date: Mon, 20 Nov 2006 03:57:06 -0800 (PST)
this response was relating how you can't use the same mutation rate for the control region as the coding region when comparing the full sequence of mtdna bases.
John McEwan <> wrote:
Am I missing something in this conversation? Yes you can hotspots for
mutation, typically these are affected by base composition and little
else. However, if the "observed" mutation rate change over time is much
lower in mitochondrial coding regions then the most likely explanation
is not that the mutation rate is lower in these regions, but that it is
a consequence of selection against changes, just as the "observed" rate
of change in genomic DNA between divergent groups or species is also
much lower in protein coding regions.
>The mutation rate for the coding region will be lower than for the
>hypervariable region, but how much lower is anyone's guess at this
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