GENEALOGY-DNA-L Archives

Archiver > GENEALOGY-DNA > 2006-12 > 1166653298


From: "William Hurst" <>
Subject: Re: [DNA] new mtDNA sequences from 'Pereira'
Date: Wed, 20 Dec 2006 17:21:38 -0500
In-Reply-To: <000d01c7244b$5a525200$0202a8c0@IanLogan>


Thanks Ian. Here are my guesses for further subclades for the K's:

>It is a good week for new mtDNA sequences as 43 'mixed' sequences have
>appeared
>on GenBank from 'Pereira'. The description of the sequences suggest they
>were collected
>from a Portuguese study of men with low fertility.
>
>The sequences are very interesting as some of them belong to very unusual
>haplogroups:
>There are:

>4 x Haplogroup K1

>EF177407(Portugal) Haplogroup K1 A73G T146C T152C A263G 309.C 315.C C498.
>A750G T1189C A1438G
>A1811G A2706G A3480G A4769G C7028T A8860G G9055A A9093G T9698C A10398G
>A10550G T11299C G11377A A11467G G11719A A12308G G12372A C14167T C14766T
>T14798C A15296G A15326G G15928A C16159T T16311C

[146C, 152C and 498- put it in K1c. 9093G and 11377A get it to K1c1.
Interesting that it's missing 16519C.]

>EF177412(Portugal) Haplogroup K1 [497T, A73G T195C A263G 315.C C497T
>A750G T1189C A1438G A1811G A2706G
>A3480G A4769G C7028T A8860G G9055A T9698C A10398G A10550G T11299C A11467G
>G11719A A12308G G12372A G12651A C14167T C14766T T14798C A15326G T16224C
>C16234T T16311C T16519C

[497T puts it into K1a. 16234T is found in several places in K1a, but this
one doesn't fit any of the nine listed subclades so it can be labeled K1a*.]

>EF177415(Portugal) Haplogroup K1
>A73G T152C T195C A263G 309.C 309.C 315.C A750G T1189C A1438G
>A1811G T2023C A2706G A3480G A4769G G5913A C7028T T8260C A8860G G9055A
>C9371T T9698C G9962A A10289G A10398G A10550G T11299C A11467G G11719A
>A11923G
>A12308G G12372A C14167T C14766T T14798C G15257A A15326G C15381T C15946T
>T16093C T16224C T16311C A16318T G16319A A16463G T16519C

[5913A puts this into K1b. 9962A, 10289G and 15946T get it to K1b1. Then it
has four out five necessary to get it to K1b1a: 152C, 11923G, 15257A and
16319A; it's missing the 13967 shown on Behar's K chart. Back mutation or
new branch? Behar then has two unlabeled groups under that; one is 16346G,
but that is certainly a transposition of the correct 16463G which this one
has. (Behar's examples are from Herrnstadt, who is one of those who
apparently don't put HVR mutations on GenBank. In the K Project, there are
11 with 16319A; 10 of them have the additional 16463G. This is a highly
diversified subclade. Of the five high-resolution examples in the K Project,
there are no exact matches. The 16318T above is interesting; there is one
HVR-only person in the K Project with that, but their listed ancestral
origin is not Portugal, it's the Cherokee Nation!]

>EF177416(Portugal) Haplogroup K1a4
>A73G A263G 315.C C497T 523.C 523.A A750G T1189C A1438G A1811G
>A2706G A3480G A4769G C7028T A7118G A8860G G9055A T9698C A10398G A10550G
>T11299C A11467G T11485C G11719A A12017G A12308G G12372A C12399T C14167T
>C14766T T14798C A15326G T16093C T16224C T16311C T16519C

[This has the 16093C to get it started down the K1a4c line, but none of the
other necessary mutations. That heteroplasmic mutation is really not a good
one for subclading.]

Bill Hurst


This thread: