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From: "Ian & Mary Logan" <>
Subject: Re: [DNA] A new 'must see' paper on African mtDNA
Date: Mon, 1 Jan 2007 10:16:14 -0000
References: <000501c72d0f$16bb9520$0202a8c0@IanLogan>


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I have now been shown a copy of this paper. (Thank you.)

It is full of detail as to how the sequencing was performed and how various
statistical tests made. However, from our point of view the main point of
the paper would appear to be the fresh diagram showing the subgroups
of Haplogroup L0 in a clear manner.

The sequences EF184580-184641 are not available as yet.

Ian

(for the next couple of weeks only)

..................
Mol Biol Evol. 2006 Dec 28;
Whole mtDNA Genome Sequence Analysis of Ancient African Lineages.

Gonder MK, Mortensen HM, Reed FA, de Sousa A, Tishkoff SA.
Department of Biology, University of Maryland, College Park, MD 20742 USA.

Studies of human mtDNA genomes demonstrate that the root of the human phylogenetic tree occurs in
Africa. Although two mtDNA lineages with an African origin (haplogroups M and N) were the
progenitors of all non-African haplogroups, macrohaplogroup L (including haplogroups L0-L6) is
limited to sub-Saharan Africa. Several L haplogroup lineages occur most frequently in eastern Africa
(e.g., L0a, L0f, L5, L3g), but some are specific to certain ethnic groups, such as haplogroup
lineages L0d and L0k that previously have been found nearly exclusively among southern African
"click" speakers. Few studies have included multiple mtDNA genome samples belonging to haplogroups
that occur in eastern and southern Africa but are rare or absent elsewhere. This lack of sampling in
eastern Africa makes it difficult to infer relationships among mtDNA haplogroups or to examine
events that occurred early in human history. We sequenced 62 complete mtDNA genomes of ethnically
diverse Tanzanians, southern African Khoisan speakers and Bakola Pygmies and compared them to a
global pool of 226 mtDNA genomes. From these, we infer phylogenetic relationships amongst mtDNA
haplogroups and estimate the time to most recent common ancestor (TMRCA) for haplogroup lineages.
These data suggest that Tanzanians have high genetic diversity and possess ancient mtDNA
haplogroups, some of which are either rare (L0d and L5) or absent (L0f) in other regions of Africa.
We propose that a large and diverse human population(s) has persisted in eastern Africa and that
eastern Africa may have been an ancient source of dispersion of modern humans both within and
outside of Africa.
...............


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