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From:
Subject: Re: [DNA] A new mtDNA paper trailed on PubMed
Date: Thu, 1 Feb 2007 16:19:34 EST


In a message dated 2/1/2007 12:21:47 PM Pacific Standard Time,
writes:

> This would be *extremely* interesting. Schizophrenia is known to be about
> 80% genetic; but if it is even partly correlated with mitochondrial DNA
> distortion, then the daughters of female schizophrenics have additional
> reason to worry about its reappearance in their own children, whereas the
> children of male schizophrenics and the sons of female schizophrenics have
> less reason to worry about passing on the illness to offspring.
>
> >[mailto:] On Behalf Of Ian
> >&Mary Logan
> >This paper is announced on PubMed - but there is no abstract.
> >
> >It is written by several important people and will be well
> >worth seeing.
> >
> >
> >Bandelt HJ, Olivieri A, Bravi C, Yao YG, Torroni A, Salas A.
> >'Distorted' mitochondrial DNA sequences in schizophrenic
> >patients. Eur J Hum Genet. 2007 Jan 31;

I'd like to see this article, too, but I'll stick my neck out here and make a
conjecture based purely on the title (not even the abstract!). Bandelt is a
fierce critic of much of the literature published by medical geneticists on
disease / mtDNA correlations. He complains that the raw sequence data quality is
poor and the interpretation fails to incorporate phylogenetic knowledge. I'd
guess this article is in the same genre, especially since it is acommpanied by
a rebuttal:

Reply to Bandelt
Lourdes Martorell and Elisabet Vilella
Eur J Hum Genet advance online publication, January 31, 2007;
doi:10.1038/sj.ejhg.5201782

Ann Turner







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